NCT02785146 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Wang X, Zhang N, Huo Q, Sun M, Dong L, Zhang Y, Xu G, Yang Q
Huaier aqueous extract inhibits stem-like characteristics of MCF7 breast cancer cells via inactivation of hedgehog pathway. Tumour Biol. 2014 Nov;35(11):10805-13. doi: 10.1007/s13277-014-2390-2
Wang X, Zhang N, Huo Q, Yang Q
Anti-angiogenic and antitumor activities of Huaier aqueous extract. Oncol Rep. 2012 Oct;28(4):1167-75. doi: 10.3892/or.2012.1961. Epub 2012 Aug 8.
Zhang N, Kong X, Yan S, Yuan C, Yang Q
Huaier aqueous extract inhibits proliferation of breast cancer cells by inducing apoptosis. Cancer Sci. 2010 Nov;101(11):2375-83. doi: 10.1111/j.1349-7006.2010.01680.x.
Zhang T, Wang K, Zhang J, Wang X, Chen Z, Ni C, Qiu F, Huang J
Huaier aqueous extract inhibits colorectal cancer stem cell growth partially via downregulation of the Wnt/ß-catenin pathway. Oncol Lett. 2013 Apr;5(4):1171-1176. Epub 2013 Jan 21.

Adjuvant Chemotherapy Combined With Huaier Granule for Treating High-risk Stage II, Stage III Colorectal Cancer

Clinical trial NCT02785146 - References