Colon Polyps — A Pilot Randomized Trial of Polypectomy Techniques for 4-6 mm Colonic Polyps
Citation(s)
Desai S, Gupta S, Copur-Dahi N, Krinsky ML A prospective randomized study comparing jumbo biopsy forceps to cold snare for the resection of diminutive colorectal polyps. Surg Endosc. 2020 Mar;34(3):1206-1213. doi: 10.1007/s00464-019-06874-z. Epub 2019 Jun 10.
Gómez V, Badillo RJ, Crook JE, Krishna M, Diehl NN, Wallace MB Diminutive colorectal polyp resection comparing hot and cold snare and cold biopsy forceps polypectomy. Results of a pilot randomized, single-center study (with videos). Endosc Int Open. 2015 Feb;3(1):E76-80. doi: 10.1055/s-0034-1390789. Epub 2014 Nov 19. Erratum in: Endosc Int Open. 2015 Feb;3(1):C1.
Lee CK, Shim JJ, Jang JY Cold snare polypectomy vs. Cold forceps polypectomy using double-biopsy technique for removal of diminutive colorectal polyps: a prospective randomized study. Am J Gastroenterol. 2013 Oct;108(10):1593-600. doi: 10.1038/ajg.2013.302. Epub 2013 Sep 17.
Tolliver KA, Rex DK Colonoscopic polypectomy. Gastroenterol Clin North Am. 2008 Mar;37(1):229-51, ix. doi: 10.1016/j.gtc.2007.12.009. Review.
A Pilot Randomized Trial of Polypectomy Techniques for 4-6 mm Colonic Polyps
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
