Gilleran JP, Thaly RK, Chernoff AM Rapid communication: bipolar PlasmaKinetic transurethral resection of the prostate: reliable training vehicle for today's urology residents. J Endourol. 2006 Sep;20(9):683-7.
Hagen B, Eriksson N, Sundset M Randomised controlled trial of LigaSure versus conventional suture ligature for abdominal hysterectomy. BJOG. 2005 Jul;112(7):968-70.
Kang SK, Kunanandam T, Clark L Prospective, case-control study of surgical efficiency of ultrasonic shear ('harmonic scalpel') thyroidectomy compared with conventional thyroidectomy. J Laryngol Otol. 2008 Nov;122(11):1194-6. doi: 10.1017/S0022215107001661. Epub 2008 Feb 19.
Kaplan B, Wang Z, Keilani T, Kaufman DB The specificity of monoclonal fluorescence polarization immunoassay for cyclosporine in recipients of simultaneous pancreas-kidney transplants. Ther Drug Monit. 1995 Oct;17(5):499-503.
Kössi J, Luostarinen M, Kontula I, Laato M Laparoscopic sigmoid and rectal resection using an electrothermal bipolar vessel sealing device. J Laparoendosc Adv Surg Tech A. 2007 Dec;17(6):719-22.
Meehan JJ The robotic Gyrus PK: a new articulating thermal sealing device and a preliminary series report. J Laparoendosc Adv Surg Tech A. 2008 Feb;18(1):183-5. doi: 10.1089/lap.2007.0179.
Sahin DA, Kusaslan R, Sahin O, Akbulut G, Bas O, Dilek ON Histopathological effects of bipolar vessel sealing devices on liver parenchyma and comparison with suture method: an experimental study. Eur Surg Res. 2007;39(2):111-7. Epub 2007 Feb 13.
Shatapathy P, Aggarwal BK, Punnen J Inferior mesenteric artery as a free arterial conduit for myocardial revascularization. J Thorac Cardiovasc Surg. 1997 Jan;113(1):210-1.
van Andel CJ, Pistecky PV, Borst C Mechanical properties of porcine and human arteries: implications for coronary anastomotic connectors. Ann Thorac Surg. 2003 Jul;76(1):58-64; discussion 64-5.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
