Cognitive Decline — Lidocaine For Neuroprotection During Cardiac Surgery
Citation(s)
Astrup J, Sørensen PM, Sørensen HR Inhibition of cerebral oxygen and glucose consumption in the dog by hypothermia, pentobarbital, and lidocaine. Anesthesiology. 1981 Sep;55(3):263-8.
Ayad M, Verity MA, Rubinstein EH Lidocaine delays cortical ischemic depolarization: relationship to electrophysiologic recovery and neuropathology. J Neurosurg Anesthesiol. 1994 Apr;6(2):98-110.
Benjamini Y, Hochberg Y Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing. J R Statist Soc B. 1995;57(1):289-300
Cronbach LJ Essentials of Psycological Testing. New York: Harper and Row; 1970
Díaz L, Gómez A, Bustos G Lidocaine reduces the hypoxia-induced release of an excitatory amino acid analog from rat striatal slices in superfusion. Prog Neuropsychopharmacol Biol Psychiatry. 1995 Sep;19(5):943-53.
Dutka AJ, Mink R, McDermott J, Clark JB, Hallenbeck JM Effect of lidocaine on somatosensory evoked response and cerebral blood flow after canine cerebral air embolism. Stroke. 1992 Oct;23(10):1515-20; discussion 1520-1.
Evans DE, Kobrine AI Reduction of experimental intracranial hypertension by lidocaine. Neurosurgery. 1987 Apr;20(4):542-7.
Fujitani T, Adachi N, Miyazaki H, Liu K, Nakamura Y, Kataoka K, Arai T Lidocaine protects hippocampal neurons against ischemic damage by preventing increase of extracellular excitatory amino acids: a microdialysis study in Mongolian gerbils. Neurosci Lett. 1994 Sep 26;179(1-2):91-4.
Goldman L, Hashimoto B, Cook EF, Loscalzo A Comparative reproducibility and validity of systems for assessing cardiovascular functional class: advantages of a new specific activity scale. Circulation. 1981 Dec;64(6):1227-34.
Johns RA, DiFazio CA, Longnecker DE Lidocaine constricts or dilates rat arterioles in a dose-dependent manner. Anesthesiology. 1985 Feb;62(2):141-4.
Lan W, Harmon D, Wang JH, Ghori K, Shorten G, Redmond P The effect of lidocaine on in vitro neutrophil and endothelial adhesion molecule expression induced by plasma obtained during tourniquet-induced ischaemia and reperfusion. Eur J Anaesthesiol. 2004 Nov;21(11):892-7.
Lei B, Popp S, Capuano-Waters C, Cottrell JE, Kass IS Lidocaine attenuates apoptosis in the ischemic penumbra and reduces infarct size after transient focal cerebral ischemia in rats. Neuroscience. 2004;125(3):691-701.
LoPachin RM, Gaughan CL, Lehning EJ, Weber ML, Taylor CP Effects of ion channel blockade on the distribution of Na, K, Ca and other elements in oxygen-glucose deprived CA1 hippocampal neurons. Neuroscience. 2001;103(4):971-83.
MacGregor RR, Thorner RE, Wright DM Lidocaine inhibits granulocyte adherence and prevents granulocyte delivery to inflammatory sites. Blood. 1980 Aug;56(2):203-9.
Mark DB, Nelson C, Delong E, et al Comparisin of quality of life outcomes following coronary angioplasty, coronary bypass surgery and medicine. J Am Coll Cardiol. 1993; 21:216A
McDowell I, Newell C Measuring Health: A Guide To Rating Scales And Questionnaires. New York: Oxford University Press; 1987.
Mitchell SJ, Benson M, Vadlamudi L, Miller P Cerebral arterial gas embolism by helium: an unusual case successfully treated with hyperbaric oxygen and lidocaine. Ann Emerg Med. 2000 Mar;35(3):300-3.
Mitchell SJ, Pellett O, Gorman DF Cerebral protection by lidocaine during cardiac operations. Ann Thorac Surg. 1999 Apr;67(4):1117-24.
Mitchell SJ Lidocaine in the treatment of decompression illness: a review of the literature. Undersea Hyperb Med. 2001 Fall;28(3):165-74. Review.
Ruff RM, Parker SB Gender- and age-specific changes in motor speed and eye-hand coordination in adults: normative values for the Finger Tapping and Grooved Pegboard Tests. Percept Mot Skills. 1993 Jun;76(3 Pt 2):1219-30.
Sakabe T, Maekawa T, Ishikawa T, Takeshita H The effects of lidocaine on canine cerebral metabolism and circulation related to the electroencephalogram. Anesthesiology. 1974 May;40(5):433-41.
Schmidt W, Schmidt H, Bauer H, Gebhard MM, Martin E Influence of lidocaine on endotoxin-induced leukocyte-endothelial cell adhesion and macromolecular leakage in vivo. Anesthesiology. 1997 Sep;87(3):617-24.
Wang D, Wu X, Li J, Xiao F, Liu X, Meng M The effect of lidocaine on early postoperative cognitive dysfunction after coronary artery bypass surgery. Anesth Analg. 2002 Nov;95(5):1134-41, table of contents.
Ware JE Jr Standards for validating health measures: definition and content. J Chronic Dis. 1987;40(6):473-80. Review.
Weber ML, Taylor CP Damage from oxygen and glucose deprivation in hippocampal slices is prevented by tetrodotoxin, lidocaine and phenytoin without blockade of action potentials. Brain Res. 1994 Nov 21;664(1-2):167-77.
Wechsler D The Wechsler Adult Intelligence Sacle-Revised (Manual): Psychological Corporation: 1981.
Zhang Y, Lipton P Cytosolic Ca2+ changes during in vitro ischemia in rat hippocampal slices: major roles for glutamate and Na+-dependent Ca2+ release from mitochondria. J Neurosci. 1999 May 1;19(9):3307-15.
Lidocaine For Neuroprotection During Cardiac Surgery
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.