Cleft Lip and Palate — Assessing the Results of Lip Surgery in Patients With Cleft Lip and Palate
Citation(s)
Andreatta RD, Barlow SM Somatosensory gating is dependent on the rate of force recruitment in the human orofacial system. J Speech Lang Hear Res. 2009 Dec;52(6):1566-78. doi: 10.1044/1092-4388(2009/08-0116). Epub 2009 Aug 28.
Barlow SM, Trotman CA, Chu SY, Lee J Modification of perioral stiffness in patients with repaired cleft lip and palate. Cleft Palate Craniofac J. 2012 Sep;49(5):524-9. doi: 10.1597/10-092. Epub 2011 Jan 19.
Chu SY, Barlow SM, Kieweg D, Lee J OroSTIFF: Face-referenced measurement of perioral stiffness in health and disease. J Biomech. 2010 May 28;43(8):1476-82. doi: 10.1016/j.jbiomech.2010.01.037. Epub 2010 Feb 24.
Chu SY, Barlow SM, Lee J Nonparticipatory stiffness in the male perioral complex. J Speech Lang Hear Res. 2009 Oct;52(5):1353-9. doi: 10.1044/1092-4388(2009/08-0101). Epub 2009 Aug 28.
Essick G, Phillips C, Chung Y, Trotman CA Effects of lip revision surgery on long-term orosensory function in patients with cleft lip/palate. Cleft Palate Craniofac J. 2013 Sep;50(5):507-12. doi: 10.1597/11-247. Epub 2012 Aug 20.
Essick GK, Phillips C, Trotman CA Functional outcomes of cleft lip surgery. Part IV: Between- and within-participant variables affecting lip vermilion sensory thresholds. Cleft Palate Craniofac J. 2007 Nov;44(6):624-34. doi: 10.1597/06-129.1.
Faraway JJ, Trotman CA Shape change along geodesics with application to cleft lip surgery. J R Stat Soc Ser C Appl Stat. 2011 Nov;60(5):743-755. Epub 2011 Sep 29.
Lee JY, Han Q, Trotman CA Three-dimensional facial imaging: accuracy and considerations for clinical applications in orthodontics. Angle Orthod. 2004 Oct;74(5):587-93.
Liu J, Xu HH, Zhou H, Weir MD, Chen Q, Trotman CA Human umbilical cord stem cell encapsulation in novel macroporous and injectable fibrin for muscle tissue engineering. Acta Biomater. 2013 Jan;9(1):4688-97. doi: 10.1016/j.actbio.2012.08.009. Epub 2012 Aug 16.
Liu J, Zhou H, Weir MD, Xu HH, Chen Q, Trotman CA Fast-degradable microbeads encapsulating human umbilical cord stem cells in alginate for muscle tissue engineering. Tissue Eng Part A. 2012 Nov;18(21-22):2303-14. doi: 10.1089/ten.TEA.2011.0658. Epub 2012 Jul 19.
Ritter K, Trotman CA, Phillips C Validity of subjective evaluations for the assessment of lip scarring and impairment. Cleft Palate Craniofac J. 2002 Nov;39(6):587-96.
Tanikawa C, Takada K, van Aalst J, Trotman CA Objective three-dimensional assessment of lip form in patients with repaired cleft lip. Cleft Palate Craniofac J. 2010 Nov;47(6):611-22. doi: 10.1597/09-099. Epub 2010 Mar 12.
Trotman CA, Barlow SM, Faraway JJ Functional outcomes of cleft lip surgery. Part III: Measurement of lip forces. Cleft Palate Craniofac J. 2007 Nov;44(6):617-23. doi: 10.1597/06-138.1.
Trotman CA, Faraway JJ, Essick GK Three-dimensional nasolabial displacement during movement in repaired cleft lip and palate patients. Plast Reconstr Surg. 2000 Apr;105(4):1273-83.
Trotman CA, Faraway JJ, Losken HW, van Aalst JA Functional outcomes of cleft lip surgery. Part II: Quantification of nasolabial movement. Cleft Palate Craniofac J. 2007 Nov;44(6):607-16. doi: 10.1597/06-125.1.
Trotman CA, Faraway JJ, Phillips C, van Aalst J Effects of lip revision surgery in cleft lip/palate patients. J Dent Res. 2010 Jul;89(7):728-32. doi: 10.1177/0022034510365485. Epub 2010 May 3.
Trotman CA, Faraway JJ, Phillips C Visual and statistical modeling of facial movement in patients with cleft lip and palate. Cleft Palate Craniofac J. 2005 May;42(3):245-54.
Trotman CA, Faraway JJ Sensitivity of a method for the analysis of facial mobility. II. Interlandmark separation. Cleft Palate Craniofac J. 1998 Mar;35(2):142-53.
Trotman CA, Phillips C, Faraway JJ, Ritter K Association between subjective and objective measures of lip form and function: an exploratory analysis. Cleft Palate Craniofac J. 2003 May;40(3):241-8.
Trotman CA Faces in 4 dimensions: Why do we care, and why the fourth dimension? Am J Orthod Dentofacial Orthop. 2011 Dec;140(6):895-9. doi: 10.1016/j.ajodo.2011.07.014.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
