NCT05882526 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Barsoum HA, ElSayed HS, El Sharaby FA, Palomo JM, Mostafa YA
Comprehensive comparison of canine retraction using NiTi closed coil springs vs elastomeric chains. Angle Orthod. 2021 Jul 1;91(4):441-448. doi: 10.2319/110620-916.1.
Davis S, Sundareswaran S, James J
Comparative evaluation of the efficiency of canine retraction using modified Marcotte and T-loop retraction springs - A split-mouth, randomized clinical trial. J Orthod Sci. 2019 May 23;8:9. doi: 10.4103/jos.JOS_101_18.

Comparative Evalutaion of the Efficiency of Maxillary Canine Retraction Using Orthodontic Elastomeric Chain Versus Burstone T-loop.A Clinical Study

Clinical trial NCT05882526 - References