NCT04336709 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Gautam S, Rajkumar B, Landge SP, Dubey S, Nehete P, Boruah LC
Antimicrobial efficacy of metapex (calcium hydroxide with iodoform formulation) at different concentrations against selected microorganisms--an in vitro study. Nepal Med Coll J. 2011 Dec;13(4):297-300.
Manzur A, González AM, Pozos A, Silva-Herzog D, Friedman S
Bacterial quantification in teeth with apical periodontitis related to instrumentation and different intracanal medications: a randomized clinical trial. J Endod. 2007 Feb;33(2):114-8.
Martinho FC, Gomes BP
Quantification of endotoxins and cultivable bacteria in root canal infection before and after chemomechanical preparation with 2.5% sodium hypochlorite. J Endod. 2008 Mar;34(3):268-72. doi: 10.1016/j.joen.2007.11.015. Epub 2008 Jan 31.
Mozayeni MA, Haeri A, Dianat O, Jafari AR
Antimicrobial effects of four intracanal medicaments on enterococcus faecalis: an in vitro study. Iran Endod J. 2014 Summer;9(3):195-8. Epub 2014 Jul 5.

Comparison of Anti-microbial Efficacy of Calcipex and Metapex in Endodontic Treatment of Chronic Apical Periodontitis

Clinical trial NCT04336709 - References