Cesarean Wound — EGF-loaded Chitosan to Facilitate Healing and Prevent Scar Formation of Cesarean Wound
Citation(s)
Anzarut A, Olson J, Singh P, Rowe BH, Tredget EE The effectiveness of pressure garment therapy for the prevention of abnormal scarring after burn injury: a meta-analysis. J Plast Reconstr Aesthet Surg. 2009 Jan;62(1):77-84. doi: 10.1016/j.bjps.2007.10.05
Baryza MJ, Baryza GA The Vancouver Scar Scale: an administration tool and its interrater reliability. J Burn Care Rehabil. 1995 Sep-Oct;16(5):535-8.
Baum CL, Arpey CJ Normal cutaneous wound healing: clinical correlation with cellular and molecular events. Dermatol Surg. 2005 Jun;31(6):674-86; discussion 686. Review.
Chan KY, Lau CL, Adeeb SM, Somasundaram S, Nasir-Zahari M A randomized, placebo-controlled, double-blind, prospective clinical trial of silicone gel in prevention of hypertrophic scar development in median sternotomy wound. Plast Reconstr Surg. 2005 Sep 15;116(4):1013-20; discussion 1021-2.
Chang CW, Ries WR Nonoperative techniques for scar management and revision. Facial Plast Surg. 2001 Nov;17(4):283-8. Review.
Chernoff WG, Cramer H, Su-Huang S The efficacy of topical silicone gel elastomers in the treatment of hypertrophic scars, keloid scars, and post-laser exfoliation erythema. Aesthetic Plast Surg. 2007 Sep-Oct;31(5):495-500.
Idriss N, Maibach HI Scar assessment scales: a dermatologic overview. Skin Res Technol. 2009 Feb;15(1):1-5. doi: 10.1111/j.1600-0846.2008.00327.x. Review.
Kelly AP Medical and surgical therapies for keloids. Dermatol Ther. 2004;17(2):212-8. Review.
Kim YS, Lew DH, Tark KC, Rah DK, Hong JP Effect of recombinant human epidermal growth factor against cutaneous scar formation in murine full-thickness wound healing. J Korean Med Sci. 2010 Apr;25(4):589-96. doi: 10.3346/jkms.2010.25.4.589. Epub 2010 Mar 19.
Lee DW, Lim C, Israelachvili JN, Hwang DS Strong adhesion and cohesion of chitosan in aqueous solutions. Langmuir. 2013 Nov 19;29(46):14222-9. doi: 10.1021/la403124u. Epub 2013 Nov 6.
Lim C, Lee DW, Israelachvili JN, Jho Y, Hwang DS Contact time- and pH-dependent adhesion and cohesion of low molecular weight chitosan coated surfaces. Carbohydr Polym. 2015 Mar 6;117:887-94. doi: 10.1016/j.carbpol.2014.10.033. Epub 2014 Nov 5.
Mao S, Sun W, Kissel T Chitosan-based formulations for delivery of DNA and siRNA. Adv Drug Deliv Rev. 2010 Jan 31;62(1):12-27. doi: 10.1016/j.addr.2009.08.004. Epub 2009 Sep 29. Review.
McCarty M An evaluation of evidence regarding application of silicone gel sheeting for the management of hypertrophic scars and keloids. J Clin Aesthet Dermatol. 2010 Nov;3(11):39-43.
Mustoe TA Evolution of silicone therapy and mechanism of action in scar management. Aesthetic Plast Surg. 2008 Jan;32(1):82-92. Epub 2007 Oct 30. Review.
O'Kane S, Ferguson MW Transforming growth factor beta s and wound healing. Int J Biochem Cell Biol. 1997 Jan;29(1):63-78. Review.
Peled ZM, Rhee SJ, Hsu M, Chang J, Krummel TM, Longaker MT The ontogeny of scarless healing II: EGF and PDGF-B gene expression in fetal rat skin and fibroblasts as a function of gestational age. Ann Plast Surg. 2001 Oct;47(4):417-24.
Perry DM, McGrouther DA, Bayat A Current tools for noninvasive objective assessment of skin scars. Plast Reconstr Surg. 2010 Sep;126(3):912-23. doi: 10.1097/PRS.0b013e3181e6046b. Review.
Reinke JM, Sorg H Wound repair and regeneration. Eur Surg Res. 2012;49(1):35-43. doi: 10.1159/000339613. Epub 2012 Jul 11. Review.
Satici A, Guzey M, Dogan Z, Kilic A Relationship between Tear TNF-alpha, TGF-beta1, and EGF levels and severity of conjunctival cicatrization in patients with inactive trachoma. Ophthalmic Res. 2003 Nov-Dec;35(6):301-5.
Shah M, Foreman DM, Ferguson MW Neutralisation of TGF-beta 1 and TGF-beta 2 or exogenous addition of TGF-beta 3 to cutaneous rat wounds reduces scarring. J Cell Sci. 1995 Mar;108 ( Pt 3):985-1002.
Shin JU, Kang SW, Jeong JJ, Nam KH, Chung WY, Lee JH Effect of recombinant human epidermal growth factor on cutaneous scar quality in thyroidectomy patients. J Dermatolog Treat. 2015 Apr;26(2):159-64. doi: 10.3109/09546634.2014.906034. Epub 2014 Apr 8.
Signorini M, Clementoni MT Clinical evaluation of a new self-drying silicone gel in the treatment of scars: a preliminary report. Aesthetic Plast Surg. 2007 Mar-Apr;31(2):183-7.
Stavrou D Neovascularisation in wound healing. J Wound Care. 2008 Jul;17(7):298-300, 302. Review.
Tyack Z, Simons M, Spinks A, Wasiak J A systematic review of the quality of burn scar rating scales for clinical and research use. Burns. 2012 Feb;38(1):6-18. doi: 10.1016/j.burns.2011.09.021. Epub 2011 Nov 1. Review.
Xue M, Jackson CJ Extracellular Matrix Reorganization During Wound Healing and Its Impact on Abnormal Scarring. Adv Wound Care (New Rochelle). 2015 Mar 1;4(3):119-136. Review.
EGF-loaded Chitosan to Facilitate Epithelial Healing And Prevent Scar Formation of Cesarean Wound
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.