Cerebrovascular Accident — Optimizing Hand Rehabilitation Post-Stroke Using Interactive Virtual Environments
Citation(s)
Adamovich SV, Fluet GG, Mathai A, Qiu Q, Lewis J, Merians AS Design of a complex virtual reality simulation to train finger motion for persons with hemiparesis: a proof of concept study. J Neuroeng Rehabil. 2009 Jul 17;6:28. doi: 10.1186/1743-0003-6-28.
Adamovich SV, Fluet GG, Merians AS, Mathai A, Qiu Q Incorporating haptic effects into three-dimensional virtual environments to train the hemiparetic upper extremity. IEEE Trans Neural Syst Rehabil Eng. 2009 Oct;17(5):512-20. doi: 10.1109/TNSRE.2009.2028
Bagce HF, Saleh S, Adamovich SV, Krakauer JW, Tunik E Corticospinal excitability is enhanced after visuomotor adaptation and depends on learning rather than performance or error. J Neurophysiol. 2013 Feb;109(4):1097-106. doi: 10.1152/jn.00304.2012. Epub 2012 Nov 28.
Bagce HF, Saleh S, Adamovich SV, Tunik E Visuomotor gain distortion alters online motor performance and enhances primary motor cortex excitability in patients with stroke. Neuromodulation. 2012 Jul;15(4):361-6. doi: 10.1111/j.1525-1403.2012.00467.x. Epub 2012 Jun 1.
Boos A, Qiu Q, Fluet GG, Adamovich SV Haptically facilitated bimanual training combined with augmented visual feedback in moderate to severe hemiplegia. Conf Proc IEEE Eng Med Biol Soc. 2011;2011:3111-4. doi: 10.1109/IEMBS.2011.6090849.
Fluet GG, Merians AS, Qiu Q, Davidow A, Adamovich SV Comparing integrated training of the hand and arm with isolated training of the same effectors in persons with stroke using haptically rendered virtual environments, a randomized clinical trial. J Neur
Puthenveettil S, Fluet G, Qiu Q, Adamovich S Classification of hand preshaping in persons with stroke using Linear Discriminant Analysis. Conf Proc IEEE Eng Med Biol Soc. 2012;2012:4563-6. doi: 10.1109/EMBC.2012.6346982.
Qiu Q, Adamovich S, Saleh S, Lafond I, Merians AS, Fluet GG A comparison of motor adaptations to robotically facilitated upper extremity task practice demonstrated by children with cerebral palsy and adults with stroke. IEEE Int Conf Rehabil Robot. 2011;
Qiu Q, Fluet GG, Lafond I, Merians AS, Adamovich SV Coordination changes demonstrated by subjects with hemiparesis performing hand-arm training using the NJIT-RAVR robotically assisted virtual rehabilitation system. Conf Proc IEEE Eng Med Biol Soc. 2009;
Rohafza M, Fluet GG, Qiu Q, Adamovich S Correlation of reaching and grasping kinematics and clinical measures of upper extremity function in persons with stroke related hemiplegia. Conf Proc IEEE Eng Med Biol Soc. 2014;2014:3610-3. doi: 10.1109/EMBC.2014
Rohafza M, Fluet GG, Qiu Q, Adamovich S Correlations between statistical models of robotically collected kinematics and clinical measures of upper extremity function. Conf Proc IEEE Eng Med Biol Soc. 2012;2012:4120-3. doi: 10.1109/EMBC.2012.6346873.
Saleh S, Adamovich SV, Tunik E Mirrored feedback in chronic stroke: recruitment and effective connectivity of ipsilesional sensorimotor networks. Neurorehabil Neural Repair. 2014 May;28(4):344-54. doi: 10.1177/1545968313513074. Epub 2013 Dec 26.
Saleh S, Adamovich SV, Tunik E Resting state functional connectivity and task-related effective connectivity changes after upper extremity rehabilitation: a pilot study. Conf Proc IEEE Eng Med Biol Soc. 2012;2012:4559-62. doi: 10.1109/EMBC.2012.6346981.
Schettino LF, Adamovich SV, Bagce H, Yarossi M, Tunik E Disruption of activity in the ventral premotor but not the anterior intraparietal area interferes with on-line correction to a haptic perturbation during grasping. J Neurosci. 2015 Feb 4;35(5):2112-7. doi: 10.1523/JNEUROSCI.3000-14.2015.
Tunik E, Adamovich SV Remapping in the ipsilesional motor cortex after VR-based training: a pilot fMRI study. Conf Proc IEEE Eng Med Biol Soc. 2009;2009:1139-42. doi: 10.1109/IEMBS.2009.5335392.
Tunik E, Saleh S, Adamovich SV Visuomotor discordance during visually-guided hand movement in virtual reality modulates sensorimotor cortical activity in healthy and hemiparetic subjects. IEEE Trans Neural Syst Rehabil Eng. 2013 Mar;21(2):198-207. doi: 10.1109/TNSRE.2013.2238250. Epub 2013 Jan 9.
Yarossi M, Adamovich S, Tunik E Sensorimotor cortex reorganization in subacute and chronic stroke: A neuronavigated TMS study. Conf Proc IEEE Eng Med Biol Soc. 2014;2014:5788-91. doi: 10.1109/EMBC.2014.6944943.
Optimizing Hand Rehabilitation Post-Stroke Using Interactive Virtual Environments
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
