Barbero M, Gatti R, Lo Conte L, Macmillan F, Coutts F, Merletti R Reliability of surface EMG matrix in locating the innervation zone of upper trapezius muscle. J Electromyogr Kinesiol. 2011 Oct;21(5):827-33. doi: 10.1016/j.jelekin.2011.05.013. Epub 2011 Jul 12.
Bron C, Dommerholt JD Etiology of myofascial trigger points. Curr Pain Headache Rep. 2012 Oct;16(5):439-44. doi: 10.1007/s11916-012-0289-4. Review.
Carpenter SE, Lynn B Vascular and sensory responses of human skin to mild injury after topical treatment with capsaicin. Br J Pharmacol. 1981 Jul;73(3):755-8.
Dideriksen JL, Holobar A, Falla D Preferential distribution of nociceptive input to motoneurons with muscle units in the cranial portion of the upper trapezius muscle. J Neurophysiol. 2016 Aug 1;116(2):611-8. doi: 10.1152/jn.01117.2015. Epub 2016 May 25.
Ertas M, Stålberg E, Falck B Can the size principle be detected in conventional EMG recordings? Muscle Nerve. 1995 Apr;18(4):435-9.
Falla D, Farina D, Graven-Nielsen T Experimental muscle pain results in reorganization of coordination among trapezius muscle subdivisions during repetitive shoulder flexion. Exp Brain Res. 2007 Apr;178(3):385-93. Epub 2006 Oct 19.
Falla D, Farina D Motor units in cranial and caudal regions of the upper trapezius muscle have different discharge rates during brief static contractions. Acta Physiol (Oxf). 2008 Apr;192(4):551-8. Epub 2007 Nov 2.
Gerwin RD, Dommerholt J, Shah JP An expansion of Simons' integrated hypothesis of trigger point formation. Curr Pain Headache Rep. 2004 Dec;8(6):468-75. Review.
Graven-Nielsen T, Arendt-Nielsen L Assessment of mechanisms in localized and widespread musculoskeletal pain. Nat Rev Rheumatol. 2010 Oct;6(10):599-606. doi: 10.1038/nrrheum.2010.107. Epub 2010 Jul 27. Review.
Henneman E, Mendell LM Functional organization of motoneuron pool and its inputs. Handbook of Physiology. The Nervous System. Motor Control. 1981;1:423-507
Holobar A, Farina D, Gazzoni M, Merletti R, Zazula D Estimating motor unit discharge patterns from high-density surface electromyogram. Clin Neurophysiol. 2009 Mar;120(3):551-62. doi: 10.1016/j.clinph.2008.10.160. Epub 2009 Feb 8.
Holobar A, Minetto MA, Botter A, Negro F, Farina D Experimental analysis of accuracy in the identification of motor unit spike trains from high-density surface EMG. IEEE Trans Neural Syst Rehabil Eng. 2010 Jun;18(3):221-9. doi: 10.1109/TNSRE.2010.2041593. Epub 2010 Feb 8.
Holobar A, Zazula D Correlation-based decomposition of surface electromyograms at low contraction forces. Med Biol Eng Comput. 2004 Jul;42(4):487-95.
Holobar A, Zazula D Multichannel blind source separation using convolution kernel compensation. IEEE Transactions on Signal Processing 2007;55(9):4487-96.
Hong CZ, Simons DG Pathophysiologic and electrophysiologic mechanisms of myofascial trigger points. Arch Phys Med Rehabil. 1998 Jul;79(7):863-72. Review.
Huynh H, Feldt LS Estimation of the Box correction for degrees of freedom from sample data in randomized block and split-plot designs. J Edu Stat 1976;1(1):69-82
Ishimaru K, Kawakita K, Sakita M Analgesic effects induced by TENS and electroacupuncture with different types of stimulating electrodes on deep tissues in human subjects. Pain. 1995 Nov;63(2):181-7.
Kim Y, Kim J, Shim JK, Suh DW, Yoon B The hypoalgesic effect of remote tactile sensory modulation on the mechanical sensitivity of trigger points: A randomized controlled study. NeuroRehabilitation. 2014;35(3):607-14. doi: 10.3233/NRE-141156.
Kumbhare DA, Ahmed S, Behr MG, Noseworthy MD Quantitative Ultrasound Using Texture Analysis of Myofascial Pain Syndrome in the Trapezius. Crit Rev Biomed Eng. 2018;46(1):1-31. doi: 10.1615/CritRevBiomedEng.2017024947.
LaMotte RH, Lundberg LE, Torebjörk HE Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin. J Physiol. 1992 Mar;448:749-64.
Masuda T, Sadoyama T Distribution of innervation zones in the human biceps brachii. J Electromyogr Kinesiol. 1991 Jun;1(2):107-15. doi: 10.1016/1050-6411(91)90004-O.
Mclean L, Urquhart N The influence of psychological stressors on myoelectrical signal activity in the shoulder region during a data entry task. Work Stress 2002;16(2):138-53
Melzack R, Stillwell DM, Fox EJ Trigger points and acupuncture points for pain: correlations and implications. Pain. 1977 Feb;3(1):3-23. Review.
Schilder A, Hoheisel U, Magerl W, Benrath J, Klein T, Treede RD Sensory findings after stimulation of the thoracolumbar fascia with hypertonic saline suggest its contribution to low back pain. Pain. 2014 Feb;155(2):222-31. doi: 10.1016/j.pain.2013.09.025. Epub 2013 Sep 26.
Schmidt-Wilcke T, Clauw DJ Fibromyalgia: from pathophysiology to therapy. Nat Rev Rheumatol. 2011 Jul 19;7(9):518-27. doi: 10.1038/nrrheum.2011.98. Review.
Shah JP, Gilliams EA Uncovering the biochemical milieu of myofascial trigger points using in vivo microdialysis: an application of muscle pain concepts to myofascial pain syndrome. J Bodyw Mov Ther. 2008 Oct;12(4):371-384. doi: 10.1016/j.jbmt.2008.06.006. Epub 2008 Aug 13. Review.
Simone DA, Baumann TK, LaMotte RH Dose-dependent pain and mechanical hyperalgesia in humans after intradermal injection of capsaicin. Pain. 1989 Jul;38(1):99-107.
Srbely JZ, Dickey JP, Bent LR, Lee D, Lowerison M Capsaicin-induced central sensitization evokes segmental increases in trigger point sensitivity in humans. J Pain. 2010 Jul;11(7):636-43. doi: 10.1016/j.jpain.2009.10.005. Epub 2009 Dec 16.
Srbely JZ New trends in the treatment and management of myofascial pain syndrome. Curr Pain Headache Rep. 2010 Oct;14(5):346-52. doi: 10.1007/s11916-010-0128-4. Review.
Szolcsányi J A pharmacological approach to elucidation of the role of different nerve fibres and receptor endings in mediation of pain. J Physiol (Paris). 1977 Sep;73(3):251-9.
Torebjörk HE, Lundberg LE, LaMotte RH Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans. J Physiol. 1992 Mar;448:765-80.
Vilensky JA, Gilman S Renaming the "Henneman size principle". Science. 1998 Jun 26;280(5372):2031.
Westad C Motor control of the upper trapezius. 2005
Woolf CJ Central sensitization: implications for the diagnosis and treatment of pain. Pain. 2011 Mar;152(3 Suppl):S2-15. doi: 10.1016/j.pain.2010.09.030. Epub 2010 Oct 18. Review.
Yu SH, Kim HJ Electrophysiological characteristics according to activity level of myofascial trigger points. J Phys Ther Sci. 2015 Sep;27(9):2841-3. doi: 10.1589/jpts.27.2841. Epub 2015 Sep 30.
Quantitative Response of Healthy Muscle Following the Induction of Capsaicin
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
