Albert CM, Chae CU, Rexrode KM, Manson JE, Kawachi I Phobic anxiety and risk of coronary heart disease and sudden cardiac death among women. Circulation. 2005 Feb 1;111(4):480-7. doi: 10.1161/01.CIR.0000153813.64165.5D.
Barr RG, Herbstman J, Speizer FE, Camargo CA Jr Validation of self-reported chronic obstructive pulmonary disease in a cohort study of nurses. Am J Epidemiol. 2002 May 15;155(10):965-71. doi: 10.1093/aje/155.10.965.
Bassuk SS, Manson JE Oral contraceptives and menopausal hormone therapy: relative and attributable risks of cardiovascular disease, cancer, and other health outcomes. Ann Epidemiol. 2015 Mar;25(3):193-200. doi: 10.1016/j.annepidem.2014.11.004. Epub 2014 Nov 13.
Bhupathiraju SN, Grodstein F, Stampfer MJ, Willett WC, Hu FB, Manson JE Exogenous Hormone Use: Oral Contraceptives, Postmenopausal Hormone Therapy, and Health Outcomes in the Nurses' Health Study. Am J Public Health. 2016 Sep;106(9):1631-7. doi: 10.2105/AJPH.2016.303349. Epub 2016 Jul 26.
Califf RM, Kramer JM What have we learned from the calcium channel blocker controversy? Circulation. 1998 Apr 28;97(16):1529-31. doi: 10.1161/01.cir.97.16.1529. No abstract available.
Colditz GA A prospective assessment of moderate alcohol intake and major chronic diseases. Ann Epidemiol. 1990 Dec;1(2):167-77. doi: 10.1016/1047-2797(90)90007-f.
Curhan GC, Willett WC, Rosner B, Stampfer MJ Frequency of analgesic use and risk of hypertension in younger women. Arch Intern Med. 2002 Oct 28;162(19):2204-8. doi: 10.1001/archinte.162.19.2204.
Forman JP, Rimm EB, Stampfer MJ, Curhan GC Folate intake and the risk of incident hypertension among US women. JAMA. 2005 Jan 19;293(3):320-9. doi: 10.1001/jama.293.3.320.
Fung TT, Willett WC, Stampfer MJ, Manson JE, Hu FB Dietary patterns and the risk of coronary heart disease in women. Arch Intern Med. 2001 Aug 13-27;161(15):1857-62. doi: 10.1001/archinte.161.15.1857.
Grodstein F, Manson JE, Stampfer MJ Postmenopausal hormone use and secondary prevention of coronary events in the nurses' health study. a prospective, observational study. Ann Intern Med. 2001 Jul 3;135(1):1-8. doi: 10.7326/0003-4819-135-1-200107030-00003.
Heianza Y, Ma W, Manson JE, Rexrode KM, Qi L Gut Microbiota Metabolites and Risk of Major Adverse Cardiovascular Disease Events and Death: A Systematic Review and Meta-Analysis of Prospective Studies. J Am Heart Assoc. 2017 Jun 29;6(7):e004947. doi: 10.1161/JAHA.116.004947.
Hu FB, Stampfer MJ, Rimm E, Ascherio A, Rosner BA, Spiegelman D, Willett WC Dietary fat and coronary heart disease: a comparison of approaches for adjusting for total energy intake and modeling repeated dietary measurements. Am J Epidemiol. 1999 Mar 15;149(6):531-40. doi: 10.1093/oxfordjournals.aje.a009849.
Hu FB, Willett WC Diet and coronary heart disease: findings from the Nurses' Health Study and Health Professionals' Follow-up Study. J Nutr Health Aging. 2001;5(3):132-8.
Hu FB Plant-based foods and prevention of cardiovascular disease: an overview. Am J Clin Nutr. 2003 Sep;78(3 Suppl):544S-551S. doi: 10.1093/ajcn/78.3.544S.
Huang T, Xu M, Lee A, Cho S, Qi L Consumption of whole grains and cereal fiber and total and cause-specific mortality: prospective analysis of 367,442 individuals. BMC Med. 2015 Mar 24;13:59. doi: 10.1186/s12916-015-0294-7. Erratum In: BMC Med. 2015;13:85.
Iso H, Rexrode K, Hennekens CH, Manson JE Application of computer tomography-oriented criteria for stroke subtype classification in a prospective study. Ann Epidemiol. 2000 Feb;10(2):81-7. doi: 10.1016/s1047-2797(99)00040-x.
Knight EL, Stampfer MJ, Hankinson SE, Spiegelman D, Curhan GC The impact of protein intake on renal function decline in women with normal renal function or mild renal insufficiency. Ann Intern Med. 2003 Mar 18;138(6):460-7. doi: 10.7326/0003-4819-138-6-200303180-00009.
Legato MJ, Johnson PA, Manson JE Consideration of Sex Differences in Medicine to Improve Health Care and Patient Outcomes. JAMA. 2016 Nov 8;316(18):1865-1866. doi: 10.1001/jama.2016.13995. No abstract available.
Liu S, Manson JE, Stampfer MJ, Holmes MD, Hu FB, Hankinson SE, Willett WC Dietary glycemic load assessed by food-frequency questionnaire in relation to plasma high-density-lipoprotein cholesterol and fasting plasma triacylglycerols in postmenopausal women. Am J Clin Nutr. 2001 Mar;73(3):560-6. doi: 10.1093/ajcn/73.3.560.
Liu S, Willett WC, Manson JE, Hu FB, Rosner B, Colditz G Relation between changes in intakes of dietary fiber and grain products and changes in weight and development of obesity among middle-aged women. Am J Clin Nutr. 2003 Nov;78(5):920-7. doi: 10.1093/ajcn/78.5.920.
Malik VS, Chiuve SE, Campos H, Rimm EB, Mozaffarian D, Hu FB, Sun Q Circulating Very-Long-Chain Saturated Fatty Acids and Incident Coronary Heart Disease in US Men and Women. Circulation. 2015 Jul 28;132(4):260-8. doi: 10.1161/CIRCULATIONAHA.114.014911. Epub 2015 Jun 5.
Manson JE, Kaunitz AM Menopause Management--Getting Clinical Care Back on Track. N Engl J Med. 2016 Mar 3;374(9):803-6. doi: 10.1056/NEJMp1514242. No abstract available.
Manson JE, Woodruff TK Reproductive Health as a Marker of Subsequent Cardiovascular Disease: The Role of Estrogen. JAMA Cardiol. 2016 Oct 1;1(7):776-777. doi: 10.1001/jamacardio.2016.2662. No abstract available.
Manson JE Postmenopausal hormone therapy and atherosclerotic disease. Am Heart J. 1994 Dec;128(6 Pt 2):1337-43. doi: 10.1016/0002-8703(94)90257-7.
Mora S, Manson JE Aspirin for Primary Prevention of Atherosclerotic Cardiovascular Disease: Advances in Diagnosis and Treatment. JAMA Intern Med. 2016 Aug 1;176(8):1195-204. doi: 10.1001/jamainternmed.2016.2648.
Oh K, Hu FB, Manson JE, Stampfer MJ, Willett WC Dietary fat intake and risk of coronary heart disease in women: 20 years of follow-up of the nurses' health study. Am J Epidemiol. 2005 Apr 1;161(7):672-9. doi: 10.1093/aje/kwi085.
Schnatz PF, Manson JE Vitamin D and cardiovascular disease: an appraisal of the evidence. Clin Chem. 2014 Apr;60(4):600-9. doi: 10.1373/clinchem.2013.211037. Epub 2013 Nov 5.
Schulze MB, Shai I, Manson JE, Li T, Rifai N, Jiang R, Hu FB Joint role of non-HDL cholesterol and glycated haemoglobin in predicting future coronary heart disease events among women with type 2 diabetes. Diabetologia. 2004 Dec;47(12):2129-36. doi: 10.1007/s00125-004-1593-2. Epub 2004 Dec 15.
Shai I, Schulze MB, Manson JE, Rexrode KM, Stampfer MJ, Mantzoros C, Hu FB A prospective study of soluble tumor necrosis factor-alpha receptor II (sTNF-RII) and risk of coronary heart disease among women with type 2 diabetes. Diabetes Care. 2005 Jun;28(6):1376-82. doi: 10.2337/diacare.28.6.1376.
Stampfer MJ, Hu FB, Manson JE, Rimm EB, Willett WC Primary prevention of coronary heart disease in women through diet and lifestyle. N Engl J Med. 2000 Jul 6;343(1):16-22. doi: 10.1056/NEJM200007063430103.
Stampfer MJ, Willett WC, Colditz GA, Speizer FE, Hennekens CH Past use of oral contraceptives and cardiovascular disease: a meta-analysis in the context of the Nurses' Health Study. Am J Obstet Gynecol. 1990 Jul;163(1 Pt 2):285-91. doi: 10.1016/0002-9378(90)90569-s.
Tanasescu M, Cho E, Manson JE, Hu FB Dietary fat and cholesterol and the risk of cardiovascular disease among women with type 2 diabetes. Am J Clin Nutr. 2004 Jun;79(6):999-1005. doi: 10.1093/ajcn/79.6.999.
Yang S, Jensen MK, Rimm EB, Willett W, Wu T Erythrocyte superoxide dismutase, glutathione peroxidase, and catalase activities and risk of coronary heart disease in generally healthy women: a prospective study. Am J Epidemiol. 2014 Nov 1;180(9):901-8. doi: 10.1093/aje/kwu195. Epub 2014 Aug 24.
Yu Z, Huang T, Zheng Y, Wang T, Heianza Y, Sun D, Campos H, Qi L PCSK9 variant, long-chain n-3 PUFAs, and risk of nonfatal myocardial infarction in Costa Rican Hispanics. Am J Clin Nutr. 2017 May;105(5):1198-1203. doi: 10.3945/ajcn.116.148106. Epub 2017 Mar 22.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.