Cardiovascular Diseases — Lipid Research Clinics Population Studies
Citation(s)
Abernathy JR, Thorn MD, Ekelund LG, Holme I, Stinnett SS, Shestov DB, Deev AD Correlates of systolic and diastolic blood pressure in men 40 to 59 years of age sampled from United States of America and Union of Soviet Socialist Republics Lipid Research Clinics populations. Am J Cardiol. 1988 May 1;61(13):1071-5.
Bangdiwala SI, Cohn R, Hazard C, Davis CE, Prineas RJ Comparisons of cause of death verification methods and costs in the lipid research clinics program mortality follow-up study. Control Clin Trials. 1989 Jun;10(2):167-87.
Barrett-Connor E, Wilcosky T, Wallace RB, Heiss G Resting and exercise electrocardiographic abnormalities associated with sex hormone use in women. The Lipid Research Clinics Program Prevalence Study. Am J Epidemiol. 1986 Jan;123(1):81-8.
Criqui MH, Mebane I, Wallace RB, Heiss G, Holdbrook MJ Multivariate correlates of adult blood pressures in nine North American populations: The Lipid Research Clinics Prevalence Study. Prev Med. 1982 Jul;11(4):391-402.
Davis CE, Gordon D, LaRosa J, Wood PD, Halperin M Correlations of plasma high-density lipoprotein cholesterol levels with other plasma lipid and lipoprotein concentrations. Circulation. 1980 Nov;62(4 Pt 2):IV24-30.
DeLong DM, DeLong ER, Wood PD, Lippel K, Rifkind BM A comparison of methods for the estimation of plasma low- and very low-density lipoprotein cholesterol. The Lipid Research Clinics Prevalence Study. JAMA. 1986 Nov 7;256(17):2372-7.
Esrey KL, Joseph L, Grover SA Relationship between dietary intake and coronary heart disease mortality: lipid research clinics prevalence follow-up study. J Clin Epidemiol. 1996 Feb;49(2):211-6.
Fisher M, Gordon T The relation of drinking and smoking habits to diet: the Lipid Research Clinics Prevalence Study. Am J Clin Nutr. 1985 Mar;41(3):623-30.
Gordon DJ, Salz KM, Roggenkamp KJ, Franklin FA Jr Dietary determinants of plasma cholesterol change in the recruitment phase of the Lipid Research Clinics Coronary Primary Prevention Trial. Arteriosclerosis. 1982 Nov-Dec;2(6):537-48.
Gordon T, Fisher M, Ernst N, Rifkind BM Relation of diet to LDL cholesterol, VLDL cholesterol, and plasma total cholesterol and triglycerides in white adults. The Lipid Research Clinics Prevalence Study. Arteriosclerosis. 1982 Nov-Dec;2(6):502-12.
Gordon T, Fisher M, Rifkind BM Some difficulties inherent in the interpretation of dietary data from free-living populations. Am J Clin Nutr. 1984 Jan;39(1):152-6.
Green MS, Heiss G, Rifkind BM, Cooper GR, Williams OD, Tyroler HA The ratio of plasma high-density lipoprotein cholesterol to total and low-density lipoprotein cholesterol: age-related changes and race and sex differences in selected North American populations. The Lipid Research Clinics Program Prevalence Study. Circulation. 1985 Jul;72(1):93-104.
Green P, Owen AR, Namboodiri K, Hewitt D, Williams LR, Elston RC The Collaborative Lipid Research Clinics Program Family Study: detection of major genes influencing lipid levels by examination of heterogeneity of familial variances. Genet Epidemiol. 1984;1(2):123-41.
Haskell WL, Taylor HL, Wood PD, Schrott H, Heiss G Strenuous physical activity, treadmill exercise test performance and plasma high-density lipoprotein cholesterol. The Lipid Research Clinics Program Prevalence Study. Circulation. 1980 Nov;62(4 Pt 2):IV53-61.
Heiss G, Johnson NJ, Reiland S, Davis CE, Tyroler HA The epidemiology of plasma high-density lipoprotein cholesterol levels. The Lipid Research Clinics Program Prevalence Study. Summary. Circulation. 1980 Nov;62(4 Pt 2):IV116-36.
Ingram DD, Thorn MD, Stinnett SS, Deev AD U.S.S.R. and U.S. nutrient intake, plasma lipids, and lipoproteins in men ages 40-59 sampled from Lipid Research Clinics populations. Prev Med. 1985 May;14(3):264-71.
Jacobs DR Jr, Barrett-Connor E Retest reliability of plasma cholesterol and triglyceride. The Lipid Research Clinics Prevalence Study. Am J Epidemiol. 1982 Dec;116(6):878-85.
Jacobs DR Jr, Mebane IL, Bangdiwala SI, Criqui MH, Tyroler HA High density lipoprotein cholesterol as a predictor of cardiovascular disease mortality in men and women: the follow-up study of the Lipid Research Clinics Prevalence Study. Am J Epidemiol. 1990 Jan;131(1):32-47.
Kalsbeek WD, Kral KM, Wallace RB, Rifkind BM Comparing mean levels of total cholesterol from visit 2 of the Lipid Research Clinics Prevalence Study with the second National Health and Nutrition Examination Survey. Am J Epidemiol. 1988 Nov;128(5):1038-53.
Knopp RH, Walden CE, Heiss G, Johnson JL, Wahl PW Prevalence and clinical correlates of beta-migrating very-low-density lipoprotein. Lipid Research Clinics Program Prevalence Study. Am J Med. 1986 Sep;81(3):493-502.
Kuba K, Lippel K, Frantz ID Jr Four electrophoretic methods compared for diagnosis of type III hyperlipoproteinemia. Clin Chem. 1979 Aug;25(8):1471-5.
Kwiterovich PO Jr, Heiss G, Johnson N, Chase GA, Tamir I, Rifkind B Assessment of plasma total cholesterol as a test to detect elevated low density (beta) lipoprotein cholesterol levels (type IIa hyperlipoproteinemia) in young subjects from a population-based sample. Am J Epidemiol. 1982 Feb;115(2):192-204.
LaRosa JC, Levy RI, Hazzard WR Some clinical implications of the results of the Lipid Research Clinics Program Prevalence Study. Circulation. 1986 Jan;73(1 Pt 2):I126-33.
Levy RI, Rifkind BM The structure, function and metabolism of high-density lipoproteins: A status report. Circulation. 1980 Nov;62(4 Pt 2):IV4-8. Review.
Morrison JA, Namboodiri K, Green P, Martin J, Glueck CJ Familial aggregation of lipids and lipoproteins and early identification of dyslipoproteinemia. The Collaborative Lipid Research Clinics Family Study. JAMA. 1983 Oct 14;250(14):1860-8.
Rifkind BM, LaRosa J Heiss G: The Prevalence of Hyperlipidemia in Selected North American Populations. In: Atherosclerosis V. Proceedings of the Fifth International Symposium on Atherosclerosis (Gotto AM, Ed) New York:Springer-Verlag, pp. 264-267; 829-830, 1980
Rifkind BM, Segal P Lipid Research Clinics Program reference values for hyperlipidemia and hypolipidemia. JAMA. 1983 Oct 14;250(14):1869-72.
Rifkind BM, Tamir I, Heiss G : Preliminary High-Density Lipoprotein Findings: The Lipid Research Clinics Program. In: Gotto AM, Jr. Miller NE, Oliver MF, (Eds), High Density Lipoproteins and Atherosclerosis. Amsterdam: Elsevier/North Holland Biomedical press, pp. 109-119, 1978
Tyroler HA, Glueck CJ, Christensen B, Kwiterovich PO Jr Plasma high-density lipoprotein cholesterol comparisons in black and white populations. The Lipid Research Clinics Program Prevalence Study. Circulation. 1980 Nov;62(4 Pt 2):IV99-107.
Tyroler HA Epidemiology of plasma high-density lipoprotein cholesterol levels. The Lipid Research Clinics Program Prevalence Study. Introduction. Circulation. 1980 Nov;62(4 Pt 2):IV1-3.
Wallace RB, Heiss G, Burrows B, Graves K Contrasting diet and body mass among users and nonusers of oral contraceptives and exogenous estrogens: the Lipid Research Clinics Program Prevalence Study. Am J Epidemiol. 1987 May;125(5):854-9.
Wilcosky T, Harris R, Weissfeld L The prevalence and correlates of Rose Questionnaire angina among women and men in the Lipid Research Clinics Program Prevalence Study population. Am J Epidemiol. 1987 Mar;125(3):400-9.
Williams OD, Heiss G , Beaglehole R, Dennis B, Bazzarre T, and Tyroler HA: Hyperlipidemia and Nutrition - Data Base and Trends. Atherosclerosis Reviews 7:145-156, 1980
Williams OD, Mowery RL, Waldman GT Common methods, different populations. The Lipid Research Clinics Program Prevalence Study. Circulation. 1980 Nov;62(4 Pt 2):IV18-23.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.