Andrews JW, Hames CG, Metts JC Jr, Waters L, Davis JM, Carpenter R Relationships between selenium and other parameters in drinking water and blood of subjects from high and low cardiovascular disease rate areas of Georgia. J Environ Pathol Toxicol. 1980 Sep;4(2-3):313-8.
Blumberg BS, Hesser JE Loci differentially affected by selection in two American black populations. Proc Natl Acad Sci U S A. 1971 Oct;68(10):2554-8.
BLUMBERG BS, WORKMAN PL, HIRSCHFELD J GAMMA-GLOBULIN, GROUP SPECIFIC, AND LIPOPROTEIN GROUPS IN A U.S. WHITE AND NEGRO POPULATION. Nature. 1964 May 9;202:561-3.
Deasy LC Some reflections on coronary heart disease: socio-medical implications for patients and their families. Soc Sci Med. 1970 Apr;3(4):659-67.
Deubner DC, Tyroler HA, Cassel JC, Hames CG, Becker C Attributable risk, population attributable risk, and population attributable fraction of death associated with hypertension in a biracial population. Circulation. 1975 Nov;52(5):901-8.
Dischinger P, Tyroler HA, McDonagh R Jr, Hames CG Blood fibrinolytic activity, social class and habitual physical activity--I. A study of black and white men in Evans County, Georgia. J Chronic Dis. 1980;33(5):283-90.
Elston RC, Namboodiri KK, Hames CG Segregation and linkage analyses of dopamine-beta-hydroxylase activity. Hum Hered. 1979;29(5):284-92.
Gryglewski RJ, Szczeklik A, Bieron K Morphine antagonises prostaglandin E1- mediated inhibition of human platelet aggregation. Nature. 1975 Jul 3;256(5512):56-7.
Halfon ST, Hames CG, Heyden S Corneal arcus and coronary heart disease mortality. Br J Ophthalmol. 1984 Aug;68(8):603-4.
HAMES CG, GREENBERG BG A comparative study of serum cholesterol levels in school children and their possible relation to atherogenesis. Am J Public Health Nations Health. 1961 Mar;51:374-85.
Hames CG, Greenlund KJ Ethnicity and cardiovascular disease: The Evans County heart study. Am J Med Sci. 1996 Mar;311(3):130-4. Erratum in: Am J Med Sci 1996 Jun;311(6):295.
Heyden S, Hames CG, Talton I Potassium-rich foods - do they do the hypertensive patient any good? J Med Assoc Ga. 1980 May;69(5):395-7.
Heyden S, Hames CG [Diet therapy of elevated blood pressure values in overweight persons. Hypertension-intervention study: 1 year's report from the Evans-County (Ga.) study]. Med Welt. 1974 Dec 6;25(49):2041-3. German.
Heyden S, Heiss G, Bartel AG, Hames CG Sex differences in coronary mortality among diabetics in Evans County, Georgia. J Chronic Dis. 1980;33(5):265-73.
Heyden S, Heiss G, Hames CG, Bartel AG Fasting triglycerides as predictors of total and CHD mortality in Evans County, Georgia. J Chronic Dis. 1980;33(5):275-82.
Heyden S, Heyden F, Heiss G, Hames CG Smoking and coffee consumption in three groups: cancer deaths, cardiovascular deaths and living controls. A prospective study in Evans County, Georgia. J Chronic Dis. 1979;32(9-10):673-7.
Ibrahim MA, Jenkins CD, Cassel JC, McDonough JR, Hames CG Personality traits and coronary heart disease. Utilization of a cross-sectional study design to test whether a selected psychological profile precedes or follows manifest coronary heart disease. J Chronic Dis. 1966 Mar;19(3):255-71.
Johnson JL, Heineman EF, Heiss G, Hames CG, Tyroler HA Cardiovascular disease risk factors and mortality among black women and white women aged 40-64 years in Evans County, Georgia. Am J Epidemiol. 1986 Feb;123(2):209-20.
Kark JD, Smith AH, Hames CG Serum retinol and the inverse relationship between serum cholesterol and cancer. Br Med J (Clin Res Ed). 1982 Jan 16;284(6310):152-4.
Kark JD, Smith AH, Hames CG The relationship of serum cholesterol to the incidence of cancer in Evans County, Georgia. J Chronic Dis. 1980;33(5):311-32.
LICHTMAN MA, HAMES CG, MCDONOUGH JR SERUM PROTEIN ELECTROPHORETIC FRACTIONS AMONG NEGRO AND WHITE SUBJECT IN EVANS COUNTY, GEORGIA. Am J Clin Nutr. 1965 Jun;16:492-508.
Lichtman MA, Vaughan JH, Hames CG The distribution of serum immunoglobulins, anti-gamma-G globulins ("rheumatoid factors") and antinuclear antibodies in White and Negro subjects in Evans County, Georgia. Arthritis Rheum. 1967 Jun;10(3):204-15.
Marazita ML, Elston RC, Namboodiri KK, Hames CG Factors contributing to the variability in serum lipid levels and blood pressure in a large kindred. Am J Epidemiol. 1983 Dec;118(6):806-17.
McAdam PA, Smith DK, Feldman EB, Hames C Effect of age, sex, and race on selenium status of healthy residents of Augusta, Georgia. Biol Trace Elem Res. 1984 Feb;6(1):3-9. doi: 10.1007/BF02918316.
PARKER WC, BEARN AG Haptoglobin and transferrin variation in humans and primates: two new transferrins in Chinese and Japanese populations. Ann Hum Genet. 1961 Dec;25:227-41.
Patzschke U, Manegold C, Wolff G [Reduction of hypertensive changes in the electrocardiogram during antihypertensive treatment]. MMW Munch Med Wochenschr. 1979 Jun 8;121(23):795-7. German.
Patzschke U, Manegold C [Electrocardiographic signs of hypokalemia under antihypertensive treatment (author's transl)]. Schweiz Rundsch Med Prax. 1979 Jul 10;68(28):908-15. German.
Peleg I, Heyden S, Knowles M, Hames CG Serum retinol and risk of subsequent cancer: extension of the Evans County, Georgia, study. J Natl Cancer Inst. 1984 Dec;73(6):1455-8.
Peleg I, Morris S, Hames CG Is serum selenium a risk factor for cancer? Med Oncol Tumor Pharmacother. 1985;2(3):157-63.
Strogatz DS, Tyroler HA, Watkins LO, Hames CG Electrocardiographic abnormalities and mortality among middle-aged black men and white men of Evans County, Georgia. J Chronic Dis. 1987;40(2):149-55.
STULB SC, MCDONOUGH JR, GREENBERG BG, HAMES CG THE RELATIONSHIP OF NUTRIENT INTAKE AND EXERCISE TO SERUM CHOLESTEROL LEVELS IN WHITE MALES IN EVANS COUNTY, GEORGIA. Am J Clin Nutr. 1965 Feb;16:238-42.
White AD, Hames CG, Tyroler HA Serum cholesterol and 20-year mortality in black and white men and women aged 65 and older in the Evans County Heart Study. Ann Epidemiol. 1992 Jan-Mar;2(1-2):85-91.
WORKMAN PL, BLUMBERG BS, COOPER AJ SELECTION, GENE MIGRATION AND POLYMORPHIC STABILITY IN A U. S. WHITE AND NEGRO POPULATION. Am J Hum Genet. 1963 Dec;15:429-37.
Wright JS, Dever GE Mortality in rural Georgia. J Med Assoc Ga. 1984 May;73(5):283-7, 291.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.