Cardiovascular Disease — World Trade Center (WTC) RENAL
Citation(s)
Bash LD, Erlinger TP, Coresh J, Marsh-Manzi J, Folsom AR, Astor BC Inflammation, hemostasis, and the risk of kidney function decline in the Atherosclerosis Risk in Communities (ARIC) Study. Am J Kidney Dis. 2009 Apr;53(4):596-605. doi: 10.1053/j.ajkd.2008.10.044. Epub 2008 Dec 24.
Ekong EB, Jaar BG, Weaver VM Lead-related nephrotoxicity: a review of the epidemiologic evidence. Kidney Int. 2006 Dec;70(12):2074-84. Epub 2006 Oct 25. Review.
El-Shehaby A, Darweesh H, El-Khatib M, Momtaz M, Marzouk S, El-Shaarawy N, Emad Y Correlations of urinary biomarkers, TNF-like weak inducer of apoptosis (TWEAK), osteoprotegerin (OPG), monocyte chemoattractant protein-1 (MCP-1), and IL-8 with lupus nephritis. J Clin Immunol. 2011 Oct;31(5):848-56. doi: 10.1007/s10875-011-9555-1. Epub 2011 Jun 21.
Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med. 2004 Sep 23;351(13):1296-305. Erratum in: N Engl J Med. 2008;18(4):4.
Lin HH, Chou SA, Yang HY, Hwang YH, Kuo CH, Kao TW, Lo TC, Chen PC Association of blood lead and mercury with estimated GFR in herbalists after the ban of herbs containing aristolochic acids in Taiwan. Occup Environ Med. 2013 Aug;70(8):545-51. doi: 10.1136/oemed-2012-101066. Epub 2013 May 23.
Mo VY, De Lemos JA Individualizing therapy in acute coronary syndromes: using a multiple biomarker approach for diagnosis, risk stratification, and guidance of therapy. Curr Cardiol Rep. 2004 Jul;6(4):273-8.
Morrow DA, Braunwald E Future of biomarkers in acute coronary syndromes: moving toward a multimarker strategy. Circulation. 2003 Jul 22;108(3):250-2.
Nadkarni GN BE Apolipoprotein L1 Gene Variants Associate with Increased Systolic and Diastolic Blood Pressure in Younger African Americans Independent of Renal Function American Society of Nephrology Kidney Week. Atlanta, GA2013.
Ommen SR, Nishimura RA, Appleton CP, Miller FA, Oh JK, Redfield MM, Tajik AJ Clinical utility of Doppler echocardiography and tissue Doppler imaging in the estimation of left ventricular filling pressures: A comparative simultaneous Doppler-catheterization study. Circulation. 2000 Oct 10;102(15):1788-94.
Quyyumi AA Circulating endothelial progenitor cells as novel biological determinants of vascular function and risk. Can J Cardiol. 2004 Aug;20 Suppl B:44B-48B.
Sattar N Inflammation and endothelial dysfunction: intimate companions in the pathogenesis of vascular disease? Clin Sci (Lond). 2004 May;106(5):443-5. Review.
Sawit S MM, Garcia-Alvarez A, Fahima DK, Maceda C, Moline J Evidence of Impaired Vascular Reactivity Following Dust Exposure in Participants of the World Trade Center Medical Monitoring and Treatment Program. New York City: Mount Sinai School of Medicine; 2011.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.