Lamagni T CK, Wloch C, Harrington P The epidemiology of cardiac surgical site infection in Englad, 2018/19. 30th European Congress of Clinical Microbiology and Infectious Diseases. 2020; Paris, France: Clin Microbiol Infect 2020.
Magboo R, Drey N, Cooper J, Byers H, Shipolini A, Sanders J Predicting cardiac surgical site infection: development and validation of the Barts Surgical Infection Risk tool. J Clin Epidemiol. 2020 Dec;128:57-65. doi: 10.1016/j.jclinepi.2020.08.015. Epub 2020 Aug 25.
Royston P, Parmar MK, Sylvester R Construction and validation of a prognostic model across several studies, with an application in superficial bladder cancer. Stat Med. 2004 Mar 30;23(6):907-26. doi: 10.1002/sim.1691.
Vergouwe Y, Moons KG, Steyerberg EW External validity of risk models: Use of benchmark values to disentangle a case-mix effect from incorrect coefficients. Am J Epidemiol. 2010 Oct 15;172(8):971-80. doi: 10.1093/aje/kwq223. Epub 2010 Aug 31.
Multi-centre Assessment of Existing Pre-operative Risk Assessment Tools for Predicting Surgical Site Infection After Cardiac Surgery
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
