Cancer — Adult and Paediatric Patient Radiation Doses From Multidetector Row Computed Tomography Scans: a National Survey
Citation(s)
Brenner DJ, Hall EJ Computed tomography--an increasing source of radiation exposure. N Engl J Med. 2007 Nov 29;357(22):2277-84. Review.
Brenner DJ, Shuryak I, Einstein AJ Impact of reduced patient life expectancy on potential cancer risks from radiologic imaging. Radiology. 2011 Oct;261(1):193-8. doi: 10.1148/radiol.11102452. Epub 2011 Jul 19.
Frush DP, Applegate K Computed tomography and radiation: understanding the issues. J Am Coll Radiol. 2004 Feb;1(2):113-9. Review.
Adult and Paediatric Patient Radiation Doses From Multidetector CT Scans: a National Survey
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
