NCT00342966 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Ankerst J, Sjögren HO
Effect of selenium on the induction of breast fibroadenomas by adenovirus type 9 and 1,2-dimethylhydrazine-induced bowel carcinogenesis in rats. Int J Cancer. 1982 Jun 15;29(6):707-10.
Bergad PL, Rathbun WB
Inhibition of Na,K-ATPase by sodium selenite and reversal by glutathione. Curr Eye Res. 1986 Dec;5(12):919-23.
Birt DF, Julius AD, Runice CE, White LT, Lawson T, Pour PM
Enhancement of BOP-induced pancreatic carcinogenesis in selenium-fed Syrian golden hamsters under specific dietary conditions. Nutr Cancer. 1988;11(1):21-33.

Characterization of the Pharmacokinetics of Oral Selenium Compounds in Humans Before and Following Supplementation

Clinical trial NCT00342966 - References