Burn Scar — Easy Way of Choosing Rectangular Expander and Getting Maximum Benefit From Expanded Tissue
Citation(s)
Hudson DA Maximising the use of tissue expanded flaps. Br J Plast Surg. 2003 Dec;56(8):784-90.
Kiyokawa K, Rikimaru H, Inoue Y, Tai Y A new concept and technique for reconstructing skin defects in the cheek region: an unfolded cube advancement flap. Plast Reconstr Surg. 2004 Mar;113(3):985-91.
NEUMANN CG The expansion of an area of skin by progressive distention of a subcutaneous balloon; use of the method for securing skin for subtotal reconstruction of the ear. Plast Reconstr Surg (1946). 1957 Feb;19(2):124-30.
Pamplona DC, Weber HI, Leta FR Optimization of the use of skin expanders. Skin Res Technol. 2014 Nov;20(4):463-72. doi: 10.1111/srt.12141. Epub 2014 Feb 17.
Radovan C Breast reconstruction after mastectomy using the temporary expander. Plast Reconstr Surg. 1982 Feb;69(2):195-208.
Radovan C Tissue expansion in soft-tissue reconstruction. Plast Reconstr Surg. 1984 Oct;74(4):482-92.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
