Clinical Trials Logo

Citation(s)

  •   Aranganathan S, Nalini N
    Efficacy of the potential chemopreventive agent, hesperetin (citrus flavanone), on 1,2-dimethylhydrazine induced colon carcinogenesis. Food Chem Toxicol. 2009 Oct;47(10):2594-600. doi: 10.1016/j.fct.2009.07.019. Epub 2009 Jul 24.
  •   Carling D, Sanders MJ, Woods A
    The regulation of AMP-activated protein kinase by upstream kinases. Int J Obes (Lond). 2008 Sep;32 Suppl 4:S55-9. doi: 10.1038/ijo.2008.124. Review.
  •   Chiranthanut N, Teekachunhatean S, Panthong A, Khonsung P, Kanjanapothi D, Lertprasertsuk N
    Toxicity evaluation of standardized extract of Gynostemma pentaphyllum Makino. J Ethnopharmacol. 2013 Aug 26;149(1):228-34. doi: 10.1016/j.jep.2013.06.027. Epub 2013 Jun 21.
  •   Dallal, G
    (2017, July 10). www.Randomization.com. Retrieved from Randomization.com: http://www.randomization.com
  •   Ding, Y
    , Tang, K., Li, F., & et al. (2010). Effects of Gypenosides from Gynostemma pentaphyllum supplementation on exercise-induced fatigue in mice. African Journal of Agricultural Research, 5(6), 707-711.
  •   Diseases, N
    I. (n.d.). www.niddk.nih.gov/health-information/weight-management. Retrieved May 6, 2019, from Weight Management: https://www.niddk.nih.gov/health-information/weight-management
  •   El-Marasy SA, Abdallah HM, El-Shenawy SM, El-Khatib AS, El-Shabrawy OA, Kenawy SA
    Anti-depressant effect of hesperidin in diabetic rats. Can J Physiol Pharmacol. 2014 Nov;92(11):945-52. doi: 10.1139/cjpp-2014-0281. Epub 2014 Sep 19.
  •   Food and Drug Administration
    (2005, March 11). Guidance for Industry on Estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteers. Federal Register, 70(140), 1-27. Retrieved from trc.
  •   Garg A, Garg S, Zaneveld LJ, Singla AK
    Chemistry and pharmacology of the Citrus bioflavonoid hesperidin. Phytother Res. 2001 Dec;15(8):655-69. Review.
  •   Gauhar R, Hwang SL, Jeong SS, Kim JE, Song H, Park DC, Song KS, Kim TY, Oh WK, Huh TL
    Heat-processed Gynostemma pentaphyllum extract improves obesity in ob/ob mice by activating AMP-activated protein kinase. Biotechnol Lett. 2012 Sep;34(9):1607-16. doi: 10.1007/s10529-012-0944-1. Epub 2012 May 11.
  •   Ghasemi T, Abnous K, Vahdati F, Mehri S, Razavi BM, Hosseinzadeh H
    Antidepressant Effect of Crocus sativus Aqueous Extract and its Effect on CREB, BDNF, and VGF Transcript and Protein Levels in Rat Hippocampus. Drug Res (Stuttg). 2015 Jul;65(7):337-43. doi: 10.1055/s-0034-1371876. Epub 2014 Apr 2.
  •   Gout B, Bourges C, Paineau-Dubreuil S
    Satiereal, a Crocus sativus L extract, reduces snacking and increases satiety in a randomized placebo-controlled study of mildly overweight, healthy women. Nutr Res. 2010 May;30(5):305-13. doi: 10.1016/j.nutres.2010.04.008.
  •   Gynostemma Extract
    (2015). Retrieved from UENSUN: http://naturalplantextract.com/herbal-extract/gynostemma-extract.html
  •   Hardie DG, Ross FA, Hawley SA
    AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol. 2012 Mar 22;13(4):251-62. doi: 10.1038/nrm3311. Review.
  •   Hardie DG
    AMP-activated protein kinase: a key system mediating metabolic responses to exercise. Med Sci Sports Exerc. 2004 Jan;36(1):28-34. Review.
  •   Hardie DG
    AMPK: a key regulator of energy balance in the single cell and the whole organism. Int J Obes (Lond). 2008 Sep;32 Suppl 4:S7-12. doi: 10.1038/ijo.2008.116. Review.
  •   Hardie DG
    Sensing of energy and nutrients by AMP-activated protein kinase. Am J Clin Nutr. 2011 Apr;93(4):891S-6. doi: 10.3945/ajcn.110.001925. Epub 2011 Feb 16. Review.
  •   Hausenblas HA, Heekin K, Mutchie HL, Anton S
    A systematic review of randomized controlled trials examining the effectiveness of saffron (Crocus sativus L.) on psychological and behavioral outcomes. J Integr Med. 2015 Jul;13(4):231-40. doi: 10.1016/S2095-4964(15)60176-5. Review.
  •   Hausenblas HA, Saha D, Dubyak PJ, Anton SD
    Saffron (Crocus sativus L.) and major depressive disorder: a meta-analysis of randomized clinical trials. J Integr Med. 2013 Nov;11(6):377-83. doi: 10.3736/jintegrmed2013056.
  •   Huyen VT, Phan DV, Thang P, Hoa NK, Ostenson CG
    Antidiabetic effect of Gynostemma pentaphyllum tea in randomly assigned type 2 diabetic patients. Horm Metab Res. 2010 May;42(5):353-7. doi: 10.1055/s-0030-1248298. Epub 2010 Mar 8.
  •   Imenshahidi M, Hosseinzadeh H, Javadpour Y
    Hypotensive effect of aqueous saffron extract (Crocus sativus L.) and its constituents, safranal and crocin, in normotensive and hypertensive rats. Phytother Res. 2010 Jul;24(7):990-4. doi: 10.1002/ptr.3044.
  •   Kaats GR, Miller H, Preuss HG, Stohs SJ
    A 60day double-blind, placebo-controlled safety study involving Citrus aurantium (bitter orange) extract. Food Chem Toxicol. 2013 May;55:358-62. doi: 10.1016/j.fct.2013.01.013. Epub 2013 Jan 25.
  •   Kamaraj S, Ramakrishnan G, Anandakumar P, Jagan S, Devaki T
    Antioxidant and anticancer efficacy of hesperidin in benzo(a)pyrene induced lung carcinogenesis in mice. Invest New Drugs. 2009 Jun;27(3):214-22. doi: 10.1007/s10637-008-9159-7. Epub 2008 Aug 13.
  •   Kianbakht, S
    , & Haiiaghaee, R. (2011). Anti-hyperglycemic effects of saffron and its active constituents, crocin and safranal, in alloxan-induced diabetic rats. Journal of Medicinal Plants, 3(39), 82-89.
  •   Kianbakht, S
    , & Mozaffari, K. (2009). Effects of saffron and its active constituents, crocin and safranal, on prevention of indomethacin-induced gastric ulcers in diabetic and nondiabetic rats. Journal of Medicinal Plants, 2(4), 30-38.
  •   Kola B
    Role of AMP-activated protein kinase in the control of appetite. J Neuroendocrinol. 2008 Jul;20(7):942-51. doi: 10.1111/j.1365-2826.2008.01745.x. Epub 2008 Apr 28. Review.
  •   Lee WJ, Koh EH, Won JC, Kim MS, Park JY, Lee KU
    Obesity: the role of hypothalamic AMP-activated protein kinase in body weight regulation. Int J Biochem Cell Biol. 2005 Nov;37(11):2254-9. Review.
  •   Li C, Schluesener H
    Health-promoting effects of the citrus flavanone hesperidin. Crit Rev Food Sci Nutr. 2017 Feb 11;57(3):613-631. Review.
  •   Li M, Lin XF, Lu J, Zhou BR, Luo D
    Hesperidin ameliorates UV radiation-induced skin damage by abrogation of oxidative stress and inflammatory in HaCaT cells. J Photochem Photobiol B. 2016 Dec;165:240-245. doi: 10.1016/j.jphotobiol.2016.10.037. Epub 2016 Nov 1.
  •   Li R, Li J, Cai L, Hu CM, Zhang L
    Suppression of adjuvant arthritis by hesperidin in rats and its mechanisms. J Pharm Pharmacol. 2008 Feb;60(2):221-8. doi: 10.1211/jpp.60.2.0011.
  •   Lin-Na S, Yong-Xiu S
    Effects of polysaccharides from Gynostemma pentaphyllum (Thunb.), Makino on physical fatigue. Afr J Tradit Complement Altern Med. 2014 Apr 3;11(3):112-7. eCollection 2014.
  •   Mashmoul M, Azlan A, Khaza'ai H, Yusof BN, Noor SM
    Saffron: A Natural Potent Antioxidant as a Promising Anti-Obesity Drug. Antioxidants (Basel). 2013 Oct 29;2(4):293-308. doi: 10.3390/antiox2040293. Review.
  •   Mishra, R
    , Joshi, D., & Jiao, G. (2011). (Gynostemma pentaphyllum), The Chinese Rasayan-Current Research Scenario. International Journal of Research in Pharmaceutical and Biomedical Sciences, 2(4), 1483-1502.
  •   Miwa Y, Mitsuzumi H, Sunayama T, Yamada M, Okada K, Kubota M, Chaen H, Mishima Y, Kibata M
    Glucosyl hesperidin lowers serum triglyceride level in hypertriglyceridemic subjects through the improvement of very low-density lipoprotein metabolic abnormality. J Nutr Sci Vitaminol (Tokyo). 2005 Dec;51(6):460-70.
  •   Miwa Y, Yamada M, Sunayama T, Mitsuzumi H, Tsuzaki Y, Chaen H, Mishima Y, Kibata M
    Effects of glucosyl hesperidin on serum lipids in hyperlipidemic subjects: preferential reduction in elevated serum triglyceride level. J Nutr Sci Vitaminol (Tokyo). 2004 Jun;50(3):211-8.
  •   Nielsen IL, Chee WS, Poulsen L, Offord-Cavin E, Rasmussen SE, Frederiksen H, Enslen M, Barron D, Horcajada MN, Williamson G
    Bioavailability is improved by enzymatic modification of the citrus flavonoid hesperidin in humans: a randomized, double-blind, crossover trial. J Nutr. 2006 Feb;136(2):404-8.
  •   Ohara T, Muroyama K, Yamamoto Y, Murosaki S
    Oral intake of a combination of glucosyl hesperidin and caffeine elicits an anti-obesity effect in healthy, moderately obese subjects: a randomized double-blind placebo-controlled trial. Nutr J. 2016 Jan 19;15:6. doi: 10.1186/s12937-016-0123-7. Erratum in: Nutr J. 2017 May 12;16(1):28.
  •   Palit S, Kar S, Sharma G, Das PK
    Hesperetin Induces Apoptosis in Breast Carcinoma by Triggering Accumulation of ROS and Activation of ASK1/JNK Pathway. J Cell Physiol. 2015 Aug;230(8):1729-39. doi: 10.1002/jcp.24818.
  •   Park SH, Huh TL, Kim SY, Oh MR, Tirupathi Pichiah PB, Chae SW, Cha YS
    Erratum: Antiobesity effect of Gynostemma pentaphyllum extract (actiponin): A randomized, double-blind, placebo-controlled trial. Obesity (Silver Spring). 2015 Dec;23(12):2520. doi: 10.1002/oby.21362.
  •   Poirier P, Giles TD, Bray GA, Hong Y, Stern JS, Pi-Sunyer FX, Eckel RH; American Heart Association; Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism
    Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation. 2006 Feb 14;113(6):898-918. Epub 2005 Dec 27. Review.
  •   Razmovski-Naumovski, V
    , Hsun-Wei Huang, T., Tran, V., & et al. (2005). Chemistry and pharmacology of Gynostemma pentaphyllum. Phytochemistry Reviews, 4, 197-219.
  •   Rizza S, Muniyappa R, Iantorno M, Kim JA, Chen H, Pullikotil P, Senese N, Tesauro M, Lauro D, Cardillo C, Quon MJ
    Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome. J Clin Endocrinol Metab. 2011 May;96(5):E782-92. doi: 10.1210/jc.2010-2879. Epub 2011 Feb 23.
  •   Rojas J, Arraiz N, Aguirre M, Velasco M, Bermúdez V
    AMPK as Target for Intervention in Childhood and Adolescent Obesity. J Obes. 2011;2011:252817. doi: 10.1155/2011/252817. Epub 2010 Dec 22.
  •   Roohbakhsh A, Parhiz H, Soltani F, Rezaee R, Iranshahi M
    Molecular mechanisms behind the biological effects of hesperidin and hesperetin for the prevention of cancer and cardiovascular diseases. Life Sci. 2015 Mar 1;124:64-74. doi: 10.1016/j.lfs.2014.12.030. Epub 2015 Jan 24. Review.
  •   Rosner, B
    (n.d.). Hypothesis Testing: Two-Sample Inference-Estimation of Sample Size and Power for Comparing Two Means. In B. Rosner, Fundamentals of Biostatistics. Cengage Learning. Retrieved from www.stat.buc.ca: https://www.stat.ubc.ca/~rollin/stats/ssize/n2.html
  •   Shehata AS, Amer MG, Abd El-Haleem MR, Karam RA
    The ability of hesperidin compared to that of insulin for preventing osteoporosis induced by type I diabetes in young male albino rats: A histological and biochemical study. Exp Toxicol Pathol. 2017 Apr 4;69(4):203-212. doi: 10.1016/j.etp.2017.01.008. Epub 2017 Jan 26.
  •   Sheng L, Qian Z, Zheng S, Xi L
    Mechanism of hypolipidemic effect of crocin in rats: crocin inhibits pancreatic lipase. Eur J Pharmacol. 2006 Aug 14;543(1-3):116-22. Epub 2006 Jun 2.
  •   Shirali S, Zahra Bathaie S, Nakhjavani M
    Effect of crocin on the insulin resistance and lipid profile of streptozotocin-induced diabetic rats. Phytother Res. 2013 Jul;27(7):1042-7. doi: 10.1002/ptr.4836. Epub 2012 Sep 5.
  •   U
    S. Food & Drug Administration. (2018, April 1). CFR- Code of Federal Regulations Title 21. Retrieved from U.S. Department of Health and Human Services: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/cfrsearch.cfm?cfrpart=182&showfr=1
  •   Ungvari Z, Parrado-Fernandez C, Csiszar A, de Cabo R
    Mechanisms underlying caloric restriction and lifespan regulation: implications for vascular aging. Circ Res. 2008 Mar 14;102(5):519-28. doi: 10.1161/CIRCRESAHA.107.168369. Review.
  •   Visnagri A, Kandhare AD, Chakravarty S, Ghosh P, Bodhankar SL
    Hesperidin, a flavanoglycone attenuates experimental diabetic neuropathy via modulation of cellular and biochemical marker to improve nerve functions. Pharm Biol. 2014 Jul;52(7):814-28. doi: 10.3109/13880209.2013.870584. Epub 2014 Feb 21.
  •   Wang M, Wang F, Wang Y, Ma X, Zhao M, Zhao C
    Metabonomics study of the therapeutic mechanism of Gynostemma pentaphyllum and atorvastatin for hyperlipidemia in rats. PLoS One. 2013 Nov 1;8(11):e78731. doi: 10.1371/journal.pone.0078731. eCollection 2013.
  •   Xi L, Qian Z, Shen X, Wen N, Zhang Y
    Crocetin prevents dexamethasone-induced insulin resistance in rats. Planta Med. 2005 Oct;71(10):917-22.

A Double-blind, Randomized, Placebo-controlled Study to Evaluate the Effects of a Weight Management Program on Body Weight in Individuals Who Are Overweight and Otherwise Healthy

Details for clinical trial NCT04107155