Angadi SS, Mookadam F, Lee CD, Tucker WJ, Haykowsky MJ, Gaesser GA High-intensity interval training vs. moderate-intensity continuous exercise training in heart failure with preserved ejection fraction: a pilot study. J Appl Physiol (1985). 2015 Sep 15;119(6):753-8. doi: 10.1152/japplphysiol.00518.2014. Epub 2014 Sep 4.
Ashor AW, Lara J, Siervo M, Celis-Morales C, Mathers JC Effects of exercise modalities on arterial stiffness and wave reflection: a systematic review and meta-analysis of randomized controlled trials. PLoS One. 2014 Oct 15;9(10):e110034. doi: 10.1371/journal.pone.0110034. eCollection 2014. Review.
Cohen ND, Dunstan DW, Robinson C, Vulikh E, Zimmet PZ, Shaw JE Improved endothelial function following a 14-month resistance exercise training program in adults with type 2 diabetes. Diabetes Res Clin Pract. 2008 Mar;79(3):405-11. Epub 2007 Nov 19.
Croymans DM, Paparisto E, Lee MM, Brandt N, Le BK, Lohan D, Lee CC, Roberts CK Resistance training improves indices of muscle insulin sensitivity and ß-cell function in overweight/obese, sedentary young men. J Appl Physiol (1985). 2013 Nov 1;115(9):1245-53. doi: 10.1152/japplphysiol.00485.2013. Epub 2013 Aug 22.
Davis CC, Ellis TJ, Amesur AK, Hewett TE, Di Stasi S IMPROVEMENTS IN KNEE EXTENSION STRENGTH ARE ASSOCIATED WITH IMPROVEMENTS IN SELF-REPORTED HIP FUNCTION FOLLOWING ARTHROSCOPY FOR FEMOROACETABULAR IMPINGEMENT SYNDROME. Int J Sports Phys Ther. 2016 Dec;11(7):1065-1075.
Dickinson JM, Volpi E, Rasmussen BB Exercise and nutrition to target protein synthesis impairments in aging skeletal muscle. Exerc Sport Sci Rev. 2013 Oct;41(4):216-23. doi: 10.1097/JES.0b013e3182a4e699. Review.
Fahs CA, Heffernan KS, Ranadive S, Jae SY, Fernhall B Muscular strength is inversely associated with aortic stiffness in young men. Med Sci Sports Exerc. 2010 Sep;42(9):1619-24. doi: 10.1249/MSS.0b013e3181d8d834.
Fleck SJ, Kraemer WJ Resistance Training: Physiological Responses and Adaptations (Part 2 of 4). Phys Sportsmed. 1988 Apr;16(4):108-24. doi: 10.1080/00913847.1988.11709485.
Gaesser GA, Tucker WJ, Jarrett CL, Angadi SS Fitness versus Fatness: Which Influences Health and Mortality Risk the Most? Curr Sports Med Rep. 2015 Jul-Aug;14(4):327-32. doi: 10.1249/JSR.0000000000000170.
Hellsten Y, Nyberg M Cardiovascular Adaptations to Exercise Training. Compr Physiol. 2015 Dec 15;6(1):1-32. doi: 10.1002/cphy.c140080. Review.
Kawano H, Tanimoto M, Yamamoto K, Sanada K, Gando Y, Tabata I, Higuchi M, Miyachi M Resistance training in men is associated with increased arterial stiffness and blood pressure but does not adversely affect endothelial function as measured by arterial reactivity to the cold pressor test. Exp Physiol. 2008 Feb;93(2):296-302. Epub 2007 Oct 2.
Micklesfield LK, Goedecke JH, Punyanitya M, Wilson KE, Kelly TL Dual-energy X-ray performs as well as clinical computed tomography for the measurement of visceral fat. Obesity (Silver Spring). 2012 May;20(5):1109-14. doi: 10.1038/oby.2011.367. Epub 2012 Jan 12.
Mihl C, Dassen WR, Kuipers H Cardiac remodelling: concentric versus eccentric hypertrophy in strength and endurance athletes. Neth Heart J. 2008 Apr;16(4):129-33.
Miyachi M Effects of resistance training on arterial stiffness: a meta-analysis. Br J Sports Med. 2013 Apr;47(6):393-6. doi: 10.1136/bjsports-2012-090488. Epub 2012 Jan 20. Review.
Okamoto T, Masuhara M, Ikuta K Effect of low-intensity resistance training on arterial function. Eur J Appl Physiol. 2011 May;111(5):743-8. doi: 10.1007/s00421-010-1702-5. Epub 2010 Oct 24.
Okamoto T, Masuhara M, Ikuta K Effects of muscle contraction timing during resistance training on vascular function. J Hum Hypertens. 2009 Jul;23(7):470-8. doi: 10.1038/jhh.2008.152. Epub 2008 Dec 18.
Okamoto T, Masuhara M, Ikuta K Upper but not lower limb resistance training increases arterial stiffness in humans. Eur J Appl Physiol. 2009 Sep;107(2):127-34. doi: 10.1007/s00421-009-1110-x. Epub 2009 Jun 17.
Spence AL, Carter HH, Naylor LH, Green DJ A prospective randomized longitudinal study involving 6 months of endurance or resistance exercise. Conduit artery adaptation in humans. J Physiol. 2013 Mar 1;591(5):1265-75. doi: 10.1113/jphysiol.2012.247387. Epub 2012 Dec 17.
Tinken TM, Thijssen DH, Black MA, Cable NT, Green DJ Time course of change in vasodilator function and capacity in response to exercise training in humans. J Physiol. 2008 Oct 15;586(20):5003-12. doi: 10.1113/jphysiol.2008.158014. Epub 2008 Aug 28.
Vlachopoulos C, Aznaouridis K, Stefanadis C Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. J Am Coll Cardiol. 2010 Mar 30;55(13):1318-27. doi: 10.1016/j.jacc.2009.10.061. Review.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.