Bagnato GL, Miceli G, Atteritano M, Marino N, Bagnato GF Far infrared emitting plaster in knee osteoarthritis: a single blinded, randomised clinical trial. Reumatismo. 2012 Dec 20;64(6):388-94. doi: 10.4081/reumatismo.2012.388.
Johnstone DM, Moro C, Stone J, Benabid AL, Mitrofanis J Turning On Lights to Stop Neurodegeneration: The Potential of Near Infrared Light Therapy in Alzheimer's and Parkinson's Disease. Front Neurosci. 2016 Jan 11;9:500. doi: 10.3389/fnins.2015.00500. eCollection 2015. Review.
Lai CH, Leung TK, Peng CW, Chang KH, Lai MJ, Lai WF, Chen SC Effects of far-infrared irradiation on myofascial neck pain: a randomized, double-blind, placebo-controlled pilot study. J Altern Complement Med. 2014 Feb;20(2):123-9. doi: 10.1089/acm.2013.0122. Epub 2013 Oct 23.
Lee CH, Roh JW, Lim CY, Hong JH, Lee JK, Min EG A multicenter, randomized, double-blind, placebo-controlled trial evaluating the efficacy and safety of a far infrared-emitting sericite belt in patients with primary dysmenorrhea. Complement Ther Med. 2011 Aug;19(4):187-93. doi: 10.1016/j.ctim.2011.06.004. Epub 2011 Jul 16.
Pastore MN, Kalia YN, Horstmann M, Roberts MS Transdermal patches: history, development and pharmacology. Br J Pharmacol. 2015 May;172(9):2179-209. doi: 10.1111/bph.13059. Epub 2015 Mar 18. Review.
Romanenko S, Begley R, Harvey AR, Hool L, Wallace VP The interaction between electromagnetic fields at megahertz, gigahertz and terahertz frequencies with cells, tissues and organisms: risks and potential. J R Soc Interface. 2017 Dec;14(137). pii: 20170585. doi: 10.1098/rsif.2017.0585. Review.
Santos LF, Correia IJ, Silva AS, Mano JF Biomaterials for drug delivery patches. Eur J Pharm Sci. 2018 Jun 15;118:49-66. doi: 10.1016/j.ejps.2018.03.020. Epub 2018 Mar 20. Review.
Tsai SR, Hamblin MR Biological effects and medical applications of infrared radiation. J Photochem Photobiol B. 2017 May;170:197-207. doi: 10.1016/j.jphotobiol.2017.04.014. Epub 2017 Apr 13. Review.
Vase L, Robinson ME, Verne GN, Price DD The contributions of suggestion, desire, and expectation to placebo effects in irritable bowel syndrome patients. An empirical investigation. Pain. 2003 Sep;105(1-2):17-25.
Vatansever F, Hamblin MR Far infrared radiation (FIR): its biological effects and medical applications. Photonics Lasers Med. 2012 Nov 1;4:255-266.
Wong CH, Lin LC, Lee HH, Liu CF The analgesic effect of thermal therapy after total knee arthroplasty. J Altern Complement Med. 2012 Feb;18(2):175-9. doi: 10.1089/acm.2010.0815.
Yang X, Zhao X, Yang K, Liu Y, Liu Y, Fu W, Luo Y Biomedical Applications of Terahertz Spectroscopy and Imaging. Trends Biotechnol. 2016 Oct;34(10):810-824. doi: 10.1016/j.tibtech.2016.04.008. Review.
Use of a Non-medicated Plaster in Chronic Lumbar Back Pain.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.