Autistic Spectrum Disorder — Dates as a Functional Food for Autism
Citation(s)
1- World Health Organization (WHO) Autism Spectrum Disorders, Fact sheet, https://www.who.int/news-room/fact-sheets/detail/autism-spectrum-disorders, acessesd on 1-7-2019, 2018
Dar-ul-Iman Healing, Food of the Prophet (Sallallaho Alayhi Wasallam) Available at: http://chishti.org/foods_of_the_prophet. acessesd on 1-7-2019, 2000
Gebril OH, Meguid NA HFE gene polymorphisms and the risk for autism in Egyptian children and impact on the effect of oxidative stress. Dis Markers. 2011;31(5):289-94. doi: 10.3233/DMA-2011-0830.
Israelyan N, Margolis KG Reprint of: Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders. Pharmacol Res. 2019 Feb;140:115-120. doi: 10.1016/j.phrs.2018.12.023. Epub 2019 Jan 15.
Kushak R , Buie T.: Intestinal disaccharidase deficiency in children with autism spectrum disorders. J. Pediatr. Gastroent. 2002; 35,:436.
Li Q, Zhou JM The microbiota-gut-brain axis and its potential therapeutic role in autism spectrum disorder. Neuroscience. 2016 Jun 2;324:131-9. doi: 10.1016/j.neuroscience.2016.03.013. Epub 2016 Mar 8. Review.
Marwat SK, Khan MA, Rehman F, Bhatti IU Aromatic plant species mentioned in the Holy Qura'n and Ahadith and their ethnomedicinal importance. Pak J Nut. 2009;8: 1472-1479.
McElhanon BO, McCracken C, Karpen S, Sharp WG Gastrointestinal symptoms in autism spectrum disorder: a meta-analysis. Pediatrics. 2014 May;133(5):872-83. doi: 10.1542/peds.2013-3995.
Meguid NA, Dardir AA, Abdel-Raouf ER, Hashish A Evaluation of oxidative stress in autism: defective antioxidant enzymes and increased lipid peroxidation. Biol Trace Elem Res. 2011 Oct;143(1):58-65. doi: 10.1007/s12011-010-8840-9. Epub 2010 Sep 16.
Perry G, Nunomura A, Harris S, Smith M, Salomon R , Is Autism a disease of oxidative stress.Oxidative stress in autism symposium, New York State, Institute for basic research in Developmental Disabilities. 2005; p. 15
Rahmani AH, Aly SM, Ali H, Babiker AY, Srikar S, Khan AA Therapeutic effects of date fruits (Phoenix dactylifera) in the prevention of diseases via modulation of anti-inflammatory, anti-oxidant and anti-tumour activity. Int J Clin Exp Med. 2014 Mar 15;7(3):483-91. eCollection 2014. Review.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.