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Harrop C, Sterrett K, Shih W, Landa R, Kaiser A, Kasari C Short-term trajectories of restricted and repetitive behaviors in minimally verbal children with autism spectrum disorder. Autism Res. 2021 Aug;14(8):1789-1799. doi: 10.1002/aur.2528. Epub 2021 Ma
Harrop C, Tu N, Landa R, Kasier A, Kasari C Sensory Behaviors in Minimally Verbal Children With Autism Spectrum Disorder: How and When Do Caregivers Respond? Am J Intellect Dev Disabil. 2018 Jan;123(1):1-16. doi: 10.1352/1944-7558-123.1.1.
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Kasari C, Shire S, Shih W, Landa R, Levato L, Smith T Spoken language outcomes in limited language preschoolers with autism and global developmental delay: RCT of early intervention approaches. Autism Res. 2023 Jun;16(6):1236-1246. doi: 10.1002/aur.2932.
Kasari C, Sturm A, Shih W SMARTer Approach to Personalizing Intervention for Children With Autism Spectrum Disorder. J Speech Lang Hear Res. 2018 Nov 8;61(11):2629-2640. doi: 10.1044/2018_JSLHR-L-RSAUT-18-0029.
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Toolan C, Holbrook A, Schlink A, Shire S, Brady N, Kasari C Using the Clinical Global Impression scale to assess social communication change in minimally verbal children with autism spectrum disorder. Autism Res. 2022 Feb;15(2):284-295. doi: 10.1002/aur.
Adaptive Interventions for Minimally Verbal Children With ASD in the Community
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.