Autism Spectrum Disorder — Cognitive Training in Children With ASD
Citation(s)
Aron AR, Poldrack RA Cortical and subcortical contributions to Stop signal response inhibition: role of the subthalamic nucleus. J Neurosci. 2006 Mar 1;26(9):2424-33.
Chein JM, Morrison AB Expanding the mind's workspace: training and transfer effects with a complex working memory span task. Psychon Bull Rev. 2010 Apr;17(2):193-9. doi: 10.3758/PBR.17.2.193.
Chevrier AD, Noseworthy MD, Schachar R Dissociation of response inhibition and performance monitoring in the stop signal task using event-related fMRI. Hum Brain Mapp. 2007 Dec;28(12):1347-58.
Cox RW AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. Comput Biomed Res. 1996 Jun;29(3):162-73.
Dahlin E, Nyberg L, Bäckman L, Neely AS Plasticity of executive functioning in young and older adults: immediate training gains, transfer, and long-term maintenance. Psychol Aging. 2008 Dec;23(4):720-30. doi: 10.1037/a0014296.
Holmes J, Gathercole SE, Dunning DL Adaptive training leads to sustained enhancement of poor working memory in children. Dev Sci. 2009 Jul;12(4):F9-15. doi: 10.1111/j.1467-7687.2009.00848.x.
Jaeggi SM, Buschkuehl M, Jonides J, Perrig WJ Improving fluid intelligence with training on working memory. Proc Natl Acad Sci U S A. 2008 May 13;105(19):6829-33. doi: 10.1073/pnas.0801268105. Epub 2008 Apr 28.
MEZZACAPPA, E & BUCKNER, J. C. 2010. Working memory training for children with attention problems or hyperactivity: A school-based pilot study. School Mental Health, 2, 202-208.
Noppeney U, Friston KJ, Price CJ Degenerate neuronal systems sustaining cognitive functions. J Anat. 2004 Dec;205(6):433-42. Review.
Richmond LL, Morrison AB, Chein JM, Olson IR Working memory training and transfer in older adults. Psychol Aging. 2011 Dec;26(4):813-22. doi: 10.1037/a0023631. Epub 2011 Jun 27.
Thaler NS, Allen DN, Park BS, McMurray JC, Mayfield J Attention processing abnormalities in children with traumatic brain injury and attention-deficit/hyperactivity disorder: differential impairment of component processes. J Clin Exp Neuropsychol. 2010 Nov;32(9):929-36. doi: 10.1080/13803391003596488. Epub 2010 Apr 16.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
