Clinical trial NCT03162120 - References

Atrial Fibrillation — Comparison of Effectiveness of Ranolazine Plus Metoprolol Combination vs. FlecainidE pluS Metoprolol Combination in ATrial Fibrillation Recurrences FOllowing PhaRmacological or Electrical CardioverSion of AtRial Fibrillation

Citation(s)

•   Aliot E, Capucci A, Crijns HJ, Goette A, Tamargo J
  Twenty-five years in the making: flecainide is safe and effective for the management of atrial fibrillation. Europace. 2011 Feb;13(2):161-73. doi: 10.1093/europace/euq382. Epub 2010 Dec 7. Review.
•   Anderson JL, Gilbert EM, Alpert BL, Henthorn RW, Waldo AL, Bhandari AK, Hawkinson RW, Pritchett EL
  Prevention of symptomatic recurrences of paroxysmal atrial fibrillation in patients initially tolerating antiarrhythmic therapy. A multicenter, double-blind, crossover study of flecainide and placebo with transtelephonic monitoring. Flecainide Supraventricular Tachycardia Study Group. Circulation. 1989 Dec;80(6):1557-70.
•   Burashnikov A, Di Diego JM, Zygmunt AC, Belardinelli L, Antzelevitch C
  Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation: differences in sodium channel inactivation between atria and ventricles and the role of ranolazine. Circulation. 2007 Sep 25;116(13):1449-57. Epub 2007 Sep 4.
•   Burashnikov A, Sicouri S, Di Diego JM, Belardinelli L, Antzelevitch C
  Synergistic effect of the combination of ranolazine and dronedarone to suppress atrial fibrillation. J Am Coll Cardiol. 2010 Oct 5;56(15):1216-24. doi: 10.1016/j.jacc.2010.08.600.
•   Capucci A, Piangerelli L, Ricciotti J, Gabrielli D, Guerra F
  Flecainide-metoprolol combination reduces atrial fibrillation clinical recurrences and improves tolerability at 1-year follow-up in persistent symptomatic atrial fibrillation. Europace. 2016 Nov;18(11):1698-1704. Epub 2016 Feb 17.
•   De Ferrari GM, Maier LS, Mont L, Schwartz PJ, Simonis G, Leschke M, Gronda E, Boriani G, Darius H, Guillamón Torán L, Savelieva I, Dusi V, Marchionni N, Quintana Rendón M, Schumacher K, Tonini G, Melani L, Giannelli S, Alberto Maggi C, Camm AJ; RAFFAELLO Investigators (see Online Supplementary Appendix for List of Participating Centers and Investigators)
  Ranolazine in the treatment of atrial fibrillation: Results of the dose-ranging RAFFAELLO (Ranolazine in Atrial Fibrillation Following An ELectricaL CardiOversion) study. Heart Rhythm. 2015 May;12(5):872-8. doi: 10.1016/j.hrthm.2015.01.021. Epub 2015 Jan 17.
•   Fragakis N, Koskinas KC, Katritsis DG, Pagourelias ED, Zografos T, Geleris P
  Comparison of effectiveness of ranolazine plus amiodarone versus amiodarone alone for conversion of recent-onset atrial fibrillation. Am J Cardiol. 2012 Sep 1;110(5):673-7. doi: 10.1016/j.amjcard.2012.04.044. Epub 2012 May 22.
•   Fragakis N, Koskinas KC, Vassilikos V
  Ranolazine as a promising treatment option for atrial fibrillation: electrophysiologic mechanisms, experimental evidence, and clinical implications. Pacing Clin Electrophysiol. 2014 Oct;37(10):1412-20. doi: 10.1111/pace.12486. Epub 2014 Aug 19. Review.
•   Kirstein M, Eickhorn R, Langenfeld H, Kochsiek K, Antoni H
  Influence of beta-adrenergic stimulation on the fast sodium current in the intact rat papillary muscle. Basic Res Cardiol. 1991 Sep-Oct;86(5):441-8.
•   Koskinas KC, Fragakis N, Katritsis D, Skeberis V, Vassilikos V
  Ranolazine enhances the efficacy of amiodarone for conversion of recent-onset atrial fibrillation. Europace. 2014 Jul;16(7):973-9. doi: 10.1093/europace/eut407. Epub 2014 Jan 27.
•   Murdock DK, Reiffel JA, Kaliebe J, Larrain G
  The Conversion of Paroxysmal or Initial Onset Atrial Fibrillation with Oral Ranolazine: Implications for a New
•   Naccarelli GV, Dorian P, Hohnloser SH, Coumel P
  Prospective comparison of flecainide versus quinidine for the treatment of paroxysmal atrial fibrillation/flutter. The Flecainide Multicenter Atrial Fibrillation Study Group. Am J Cardiol. 1996 Jan 25;77(3):53A-59A.
•   Schubert B, Vandongen AM, Kirsch GE, Brown AM
  Inhibition of cardiac Na+ currents by isoproterenol. Am J Physiol. 1990 Apr;258(4 Pt 2):H977-82.
•   Sicouri S, Burashnikov A, Belardinelli L, Antzelevitch C
  Synergistic electrophysiologic and antiarrhythmic effects of the combination of ranolazine and chronic amiodarone in canine atria. Circ Arrhythm Electrophysiol. 2010 Feb;3(1):88-95. doi: 10.1161/CIRCEP.109.886275. Epub 2009 Dec 1.
•   Sicouri S, Glass A, Belardinelli L, Antzelevitch C
  Antiarrhythmic effects of ranolazine in canine pulmonary vein sleeve preparations. Heart Rhythm. 2008 Jul;5(7):1019-26. doi: 10.1016/j.hrthm.2008.03.018. Epub 2008 Mar 21.
•   Stewart S, Hart CL, Hole DJ, McMurray JJ
  Population prevalence, incidence, and predictors of atrial fibrillation in the Renfrew/Paisley study. Heart. 2001 Nov;86(5):516-21.
•   van Wijk LM, den Heijer P, Crijns HJ, van Gilst WH, Lie KI
  Flecainide versus quinidine in the prevention of paroxysms of atrial fibrillation. J Cardiovasc Pharmacol. 1989 Jan;13(1):32-6.

A Single Site, Interventional, Comparative Study to Evaluate the Safety and Efficacy of Ranolazine Plus Metoprolol Combination vs. FlecainidE pluS Metoprolol Combination in ATrial Fibrillation Recurrences

Details for clinical trial NCT03162120