Carey VJ, Weiss ST, Tager IB, Leeder SR, Speizer FE Airways responsiveness, wheeze onset, and recurrent asthma episodes in young adolescents. The East Boston Childhood Respiratory Disease Cohort. Am J Respir Crit Care Med. 1996 Jan;153(1):356-61.
Lee J, Sparrow D, Vokonas PS, Landsberg L, Weiss ST Uric acid and coronary heart disease risk: evidence for a role of uric acid in the obesity-insulin resistance syndrome. The Normative Aging Study. Am J Epidemiol. 1995 Aug 1;142(3):288-94.
Muñoz A, Weiss ST, Tager IB, Rosner B, Speizer FE Statistical methods for the analysis of the association between bronchial responsiveness and pulmonary function changes. Bull Eur Physiopathol Respir. 1987 Jul-Aug;23(4):377-81.
O'Connor GT, Weiss ST, Tager IB, Speizer FE The effect of passive smoking on pulmonary function and nonspecific bronchial responsiveness in a population-based sample of children and young adults. Am Rev Respir Dis. 1987 Apr;135(4):800-4. Erratum in: Am Rev Respir Dis 1987 Aug;136(2):532.
Pichurko BM, Weiss ST The role of infection in asthma: implications for antibiotic therapy. Compr Ther. 1984 Mar;10(3):32-6.
Redline S, Tager IB, Segal MR, Gold D, Speizer FE, Weiss ST The relationship between longitudinal change in pulmonary function and nonspecific airway responsiveness in children and young adults. Am Rev Respir Dis. 1989 Jul;140(1):179-84.
Redline S, Tager IB, Speizer FE, Rosner B, Weiss ST Longitudinal variability in airway responsiveness in a population-based sample of children and young adults. Intrinsic and extrinsic contributing factors. Am Rev Respir Dis. 1989 Jul;140(1):172-8.
Rosner B, Munoz A Autoregressive modelling for the analysis of longitudinal data with unequally spaced examinations. Stat Med. 1988 Jan-Feb;7(1-2):59-71.
Schwartz J, Weiss ST Relationship of skin test reactivity to decrements in pulmonary function in children with asthma or frequent wheezing. Am J Respir Crit Care Med. 1995 Dec;152(6 Pt 1):2176-80.
Sparrow D, O'Connor GT, Rosner B, Weiss ST Predictors of longitudinal change in methacholine airway responsiveness among middle-aged and older men: the Normative Aging Study. Am J Respir Crit Care Med. 1994 Feb;149(2 Pt 1):376-81.
Tager IB, Segal MR, Munoz A, Weiss ST, Speizer FE The effect of maternal cigarette smoking on the pulmonary function of children and adolescents. Analyses of data from two populations. Am Rev Respir Dis. 1987 Dec;136(6):1366-70.
Tager IB, Segal MR, Speizer FE, Weiss ST The natural history of forced expiratory volumes. Effect of cigarette smoking and respiratory symptoms. Am Rev Respir Dis. 1988 Oct;138(4):837-49.
Tager IB, Weiss ST, Speizer FE Occurrence of asthma, nonspecific bronchial hyperresponsiveness and atopy. Insights from cross-sectional epidemiologic studies. Chest. 1987 Jun;91(6 Suppl):114S-119S. Review.
Tollerud DJ, Weiss ST, Leung DY Elevated soluble interleukin-2 receptors in young healthy cigarette smokers: lack of association with atopy or airways hyperresponsiveness. Int Arch Allergy Immunol. 1992;97(1):25-30.
Weiss ST, Segal MR, Sparrow D, Wager C Relation of FEV1 and peripheral blood leukocyte count to total mortality. The Normative Aging Study. Am J Epidemiol. 1995 Sep 1;142(5):493-8; discussion 499-503.
Weiss ST, Sparrow D, O'Connor GT The interrelationship among allergy, airways responsiveness, and asthma. J Asthma. 1993;30(5):329-49. Review.
Weiss ST, Speizer FE Increased levels of airways responsiveness as a risk factor for development of chronic obstructive lung disease. What are the issues? Chest. 1984 Jul;86(1):3-4.
Weiss ST, Tager IB, Muñoz A, Speizer FE The relationship of respiratory infections in early childhood to the occurrence of increased levels of bronchial responsiveness and atopy. Am Rev Respir Dis. 1985 Apr;131(4):573-8.
Weiss ST, Tager IB, Speizer FE, Rosner B Persistent wheeze. Its relation to respiratory illness, cigarette smoking, and level of pulmonary function in a population sample of children. Am Rev Respir Dis. 1980 Nov;122(5):697-707.
Weiss ST, Tager IB, Speizer FE Passive smoking. Its relationship to respiratory symptoms, pulmonary function and nonspecific bronchial responsiveness. Chest. 1983 Dec;84(6):651-2.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.