NCT05350228 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Ghaeminia H, Meijer GJ, Soehardi A, Borstlap WA, Mulder J, Bergé SJ
Position of the impacted third molar in relation to the mandibular canal. Diagnostic accuracy of cone beam computed tomography compared with panoramic radiography. Int J Oral Maxillofac Surg. 2009 Sep;38(9):964-71. doi: 10.1016/j.ijom.2009.06.007. Epub 2009 Jul 28.
Gülicher D, Gerlach KL
Sensory impairment of the lingual and inferior alveolar nerves following removal of impacted mandibular third molars. Int J Oral Maxillofac Surg. 2001 Aug;30(4):306-12.
Kim JW, Cha IH, Kim SJ, Kim MR
Which risk factors are associated with neurosensory deficits of inferior alveolar nerve after mandibular third molar extraction? J Oral Maxillofac Surg. 2012 Nov;70(11):2508-14. doi: 10.1016/j.joms.2012.06.004. Epub 2012 Aug 15.
Kwak GH, Kwak EJ, Song JM, Park HR, Jung YH, Cho BH, Hui P, Hwang JJ
Automatic mandibular canal detection using a deep convolutional neural network. Sci Rep. 2020 Mar 31;10(1):5711. doi: 10.1038/s41598-020-62586-8.
Leung YY, Cheung LK
Risk factors of neurosensory deficits in lower third molar surgery: an literature review of prospective studies. Int J Oral Maxillofac Surg. 2011 Jan;40(1):1-10. doi: 10.1016/j.ijom.2010.09.005. Epub 2010 Oct 28. Review.
Tay AB, Go WS
Effect of exposed inferior alveolar neurovascular bundle during surgical removal of impacted lower third molars. J Oral Maxillofac Surg. 2004 May;62(5):592-600.

Accuracy of Computer-aided Evaluation of the Relationship Between Mandibular Third Molar and Mandibular Canal on CBCT Images Using Deep Learning Model (Artificial Intelligence): Diagnostic Accuracy Study.

Details for clinical trial NCT05350228

Clinical trial NCT05350228 - References