Andriacchi TP, Galante JO, Fermier RW The influence of total knee-replacement design on walking and stair-climbing. J Bone Joint Surg Am. 1982 Dec;64(9):1328-35.
Braito M, Giesinger JM, Fischler S, Koller A, Niederseer D, Liebensteiner MC Knee Extensor Strength and Gait Characteristics After Minimally Invasive Unicondylar Knee Arthroplasty vs Minimally Invasive Total Knee Arthroplasty: A Nonrandomized Controlled Trial. J Arthroplasty. 2016 Aug;31(8):1711-6. doi: 10.1016/j.arth.2016.01.045. Epub 2016 Feb 10.
Deschamps G, Lapeyre B [Rupture of the anterior cruciate ligament: a frequently unrecognized cause of failure of unicompartmental knee prostheses. Apropos of a series of 79 Lotus prostheses with a follow-up of more than 5 years]. Rev Chir Orthop Reparatrice Appar Mot. 1987;73(7):544-51. French.
Doig GS, Simpson F Randomization and allocation concealment: a practical guide for researchers. J Crit Care. 2005 Jun;20(2):187-91; discussion 191-3.
Fenner VU, Behrend H, Kuster MS Joint Mechanics After Total Knee Arthroplasty While Descending Stairs. J Arthroplasty. 2017 Feb;32(2):575-580. doi: 10.1016/j.arth.2016.07.035. Epub 2016 Aug 13.
Komnik I, Peters M, Funken J, David S, Weiss S, Potthast W Non-Sagittal Knee Joint Kinematics and Kinetics during Gait on Level and Sloped Grounds with Unicompartmental and Total Knee Arthroplasty Patients. PLoS One. 2016 Dec 21;11(12):e0168566. doi: 10.1371/journal.pone.0168566. eCollection 2016.
Komnik I, Weiss S, Fantini Pagani CH, Potthast W Motion analysis of patients after knee arthroplasty during activities of daily living--a systematic review. Gait Posture. 2015 Feb;41(2):370-7. doi: 10.1016/j.gaitpost.2015.01.019. Epub 2015 Jan 28. Review.
Liddle AD, Judge A, Pandit H, Murray DW Adverse outcomes after total and unicompartmental knee replacement in 101,330 matched patients: a study of data from the National Joint Registry for England and Wales. Lancet. 2014 Oct 18;384(9952):1437-45. Erratum in: Lancet. 2015 Feb 28;385(9970):774.
Sculco TP Orthopaedic crossfire--can we justify unicondylar arthroplasty as a temporizing procedure? in opposition. J Arthroplasty. 2002 Jun;17(4 Suppl 1):56-8.
Svärd UC, Price AJ Oxford medial unicompartmental knee arthroplasty. A survival analysis of an independent series. J Bone Joint Surg Br. 2001 Mar;83(2):191-4.
Wiik AV, Aqil A, Tankard S, Amis AA, Cobb JP Downhill walking gait pattern discriminates between types of knee arthroplasty: improved physiological knee functionality in UKA versus TKA. Knee Surg Sports Traumatol Arthrosc. 2015 Jun;23(6):1748-55. doi: 10.1007/s00167-014-3240-x. Epub 2014 Aug 27.
Willis-Owen CA, Brust K, Alsop H, Miraldo M, Cobb JP Unicondylar knee arthroplasty in the UK National Health Service: an analysis of candidacy, outcome and cost efficacy. Knee. 2009 Dec;16(6):473-8. doi: 10.1016/j.knee.2009.04.006. Epub 2009 May 22.
PPK: A Functional and Clinical Comparison of a Partial and Total Knee Replacement
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
