Anxiety — Focal Breast Pain: Does a Normal Ultrasound Provide Reassurance?
Citation(s)
Barton MB, Elmore JG, Fletcher SW Breast symptoms among women enrolled in a health maintenance organization: frequency, evaluation, and outcome. Ann Intern Med. 1999 Apr 20;130(8):651-7. doi: 10.7326/0003-4819-130-8-199904200-00005.
Duijm LE, Guit GL, Hendriks JH, Zaat JO, Mali WP Value of breast imaging in women with painful breasts: observational follow up study. BMJ. 1998 Nov 28;317(7171):1492-5. doi: 10.1136/bmj.317.7171.1492.
Harvey JA, Mahoney MC, Newell MS, et al ACR Appropriateness Criteria® palpable breast masses. Available at http://www.acr.org/~/media/ACR/Documents/AppCriteria/Diagnostic/PalpableBreastMasses.pdf. American College of Radiology. Accessed June 20, 2015.
Howard MB, Battaglia T, Prout M, Freund K The effect of imaging on the clinical management of breast pain. J Gen Intern Med. 2012 Jul;27(7):817-24. doi: 10.1007/s11606-011-1982-4. Epub 2012 Jan 31.
Jokich P, Newell MS, Bailey L, et al ACR Appropriateness Criteria® breast pain. Available at http://www.acr.org/~/media/ACR/Documents/AppCriteria/Diagnostic/ BreastPain.pdf. American College of Radiology. Accessed June 20, 2015.
Morrow M The evaluation of common breast problems. Am Fam Physician. 2000 Apr 15;61(8):2371-8, 2385.
Noroozian M, Stein LF, Gaetke-Udager K, Helvie MA Long-term clinical outcomes in women with breast pain in the absence of additional clinical findings: mammography remains indicated. Breast Cancer Res Treat. 2015 Jan;149(2):417-24. doi: 10.1007/s10549-014-3257-3. Epub 2015 Jan 6.
Olcucuoglu E, Yilmaz G Mastodynia: is imaging necessary in young patients? Ulus Cerrahi Derg. 2013 Mar 1;29(1):17-9. doi: 10.5152/UCD.2013.04. eCollection 2013.
Tumyan L, Hoyt AC, Bassett LW Negative predictive value of sonography and mammography in patients with focal breast pain. Breast J. 2005 Sep-Oct;11(5):333-7. doi: 10.1111/j.1075-122X.2005.00018.x.
Vaidyanathan L, Barnard K, Elnicki DM Benign breast disease: when to treat, when to reassure, when to refer. Cleve Clin J Med. 2002 May;69(5):425-32. doi: 10.3949/ccjm.69.5.425.
Focal Breast Pain: Does a Normal Ultrasound Provide Reassurance?
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
