Anesthesia — Correlate of Surface Electroencephalogram (EEG) With Implanted EEG Recordings (ECOG)
Citation(s)
Asano E, Brown EC, Juhasz C How to establish causality in epilepsy surgery. Brain Dev. 2013 Sep;35(8):706-20. doi: 10.1016/j.braindev.2013.04.004. Epub 2013 May 15.
Fahy BG, Chau DF The Technology of Processed Electroencephalogram Monitoring Devices for Assessment of Depth of Anesthesia. Anesth Analg. 2018 Jan;126(1):111-117. doi: 10.1213/ANE.0000000000002331.
Hajat Z, Ahmad N, Andrzejowski J The role and limitations of EEG-based depth of anaesthesia monitoring in theatres and intensive care. Anaesthesia. 2017 Jan;72 Suppl 1:38-47. doi: 10.1111/anae.13739.
Purdon PL, Sampson A, Pavone KJ, Brown EN Clinical Electroencephalography for Anesthesiologists: Part I: Background and Basic Signatures. Anesthesiology. 2015 Oct;123(4):937-60. doi: 10.1097/ALN.0000000000000841.
Ramantani G, Maillard L, Koessler L Correlation of invasive EEG and scalp EEG. Seizure. 2016 Oct;41:196-200. doi: 10.1016/j.seizure.2016.05.018. Epub 2016 Jun 10.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
