Anton S, Ezzati A, Witt D, McLaren C, Vial P The effects of intermittent fasting regimens in middle-age and older adults: Current state of evidence. Exp Gerontol. 2021 Dec;156:111617. doi: 10.1016/j.exger.2021.111617. Epub 2021 Oct 30.
Anton S, Leeuwenburgh C Fasting or caloric restriction for healthy aging. Exp Gerontol. 2013 Oct;48(10):1003-5. doi: 10.1016/j.exger.2013.04.011. Epub 2013 Apr 29.
Anton SD, Karabetian C, Naugle K, Buford TW Obesity and diabetes as accelerators of functional decline: can lifestyle interventions maintain functional status in high risk older adults? Exp Gerontol. 2013 Sep;48(9):888-97. doi: 10.1016/j.exger.2013.06.007. Epub 2013 Jul 4.
Balsamo M, Innamorati M, Van Dam NT, Carlucci L, Saggino A Measuring anxiety in the elderly: psychometric properties of the state trait inventory of cognitive and somatic anxiety (STICSA) in an elderly Italian sample. Int Psychogeriatr. 2015 Jun;27(6):999-1008. doi: 10.1017/S1041610214002634. Epub 2015 Jan 16.
Bandura A Health promotion by social cognitive means. Health Educ Behav. 2004 Apr;31(2):143-64. doi: 10.1177/1090198104263660.
Belsky DW, Huffman KM, Pieper CF, Shalev I, Kraus WE Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis. J Gerontol A Biol Sci Med Sci. 2017 Dec 12;73(1):4-10. doi: 10.1093/gerona/glx096.
de Cabo R, Mattson MP Effects of Intermittent Fasting on Health, Aging, and Disease. N Engl J Med. 2019 Dec 26;381(26):2541-2551. doi: 10.1056/NEJMra1905136. No abstract available. Erratum In: N Engl J Med. 2020 Jan 16;382(3):298. N Engl J Med. 2020 Mar 5;382(10):978.
Dhana K, Evans DA, Rajan KB, Bennett DA, Morris MC Healthy lifestyle and the risk of Alzheimer dementia: Findings from 2 longitudinal studies. Neurology. 2020 Jul 28;95(4):e374-e383. doi: 10.1212/WNL.0000000000009816. Epub 2020 Jun 17.
Engin A The Definition and Prevalence of Obesity and Metabolic Syndrome. Adv Exp Med Biol. 2017;960:1-17. doi: 10.1007/978-3-319-48382-5_1.
Feigin VL, Vos T Global Burden of Neurological Disorders: From Global Burden of Disease Estimates to Actions. Neuroepidemiology. 2019;52(1-2):1-2. doi: 10.1159/000495197. Epub 2018 Nov 23. No abstract available.
Hobson VL, Hall JR, Humphreys-Clark JD, Schrimsher GW, O'Bryant SE Identifying functional impairment with scores from the repeatable battery for the assessment of neuropsychological status (RBANS). Int J Geriatr Psychiatry. 2010 May;25(5):525-30. doi: 10.1002/gps.2382.
Hood S, Amir S The aging clock: circadian rhythms and later life. J Clin Invest. 2017 Feb 1;127(2):437-446. doi: 10.1172/JCI90328. Epub 2017 Feb 1.
Hossain P, Kawar B, El Nahas M Obesity and diabetes in the developing world--a growing challenge. N Engl J Med. 2007 Jan 18;356(3):213-5. doi: 10.1056/NEJMp068177. No abstract available. Erratum In: N Engl J Med. 2007 Mar 1;356(9):973.
J R.V., M., Sleep in mild cognitive impairment and dementia. , in APA handbook of dementia, G.E.S.S.T. Farias, Editor. 2018, American Psychological Association. p. 519-532.
Kalyani RR, Egan JM Diabetes and altered glucose metabolism with aging. Endocrinol Metab Clin North Am. 2013 Jun;42(2):333-47. doi: 10.1016/j.ecl.2013.02.010. Epub 2013 Mar 22.
Liu Y, Liu F, Grundke-Iqbal I, Iqbal K, Gong CX Brain glucose transporters, O-GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer's disease. J Neurochem. 2009 Oct;111(1):242-9. doi: 10.1111/j.1471-4159.2009.06320.x. Epub 2009 Jul 31.
Manoogian ENC, Panda S Circadian rhythms, time-restricted feeding, and healthy aging. Ageing Res Rev. 2017 Oct;39:59-67. doi: 10.1016/j.arr.2016.12.006. Epub 2016 Dec 23.
Matthews KA, Xu W, Gaglioti AH, Holt JB, Croft JB, Mack D, McGuire LC Racial and ethnic estimates of Alzheimer's disease and related dementias in the United States (2015-2060) in adults aged >/=65 years. Alzheimers Dement. 2019 Jan;15(1):17-24. doi: 10.1016/j.jalz.2018.06.3063. Epub 2018 Sep 19.
Mattson MP, Longo VD, Harvie M Impact of intermittent fasting on health and disease processes. Ageing Res Rev. 2017 Oct;39:46-58. doi: 10.1016/j.arr.2016.10.005. Epub 2016 Oct 31.
Meier-Ruge W, Bertoni-Freddari C, Iwangoff P Changes in brain glucose metabolism as a key to the pathogenesis of Alzheimer's disease. Gerontology. 1994;40(5):246-52. doi: 10.1159/000213592.
Mindikoglu AL, Abdulsada MM, Jain A, Choi JM, Jalal PK, Devaraj S, Mezzari MP, Petrosino JF, Opekun AR, Jung SY Intermittent fasting from dawn to sunset for 30 consecutive days is associated with anticancer proteomic signature and upregulates key regulatory proteins of glucose and lipid metabolism, circadian clock, DNA repair, cytoskeleton remodeling, immune system and cognitive function in healthy subjects. J Proteomics. 2020 Apr 15;217:103645. doi: 10.1016/j.jprot.2020.103645. Epub 2020 Jan 9.
Paoli A, Tinsley G, Bianco A, Moro T The Influence of Meal Frequency and Timing on Health in Humans: The Role of Fasting. Nutrients. 2019 Mar 28;11(4):719. doi: 10.3390/nu11040719.
Rajan KB, Weuve J, Barnes LL, McAninch EA, Wilson RS, Evans DA Population estimate of people with clinical Alzheimer's disease and mild cognitive impairment in the United States (2020-2060). Alzheimers Dement. 2021 Dec;17(12):1966-1975. doi: 10.1002/alz.12362. Epub 2021 May 27.
Randolph C, Tierney MC, Mohr E, Chase TN The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS): preliminary clinical validity. J Clin Exp Neuropsychol. 1998 Jun;20(3):310-9. doi: 10.1076/jcen.20.3.310.823.
Razay G, Vreugdenhil A, Wilcock G The metabolic syndrome and Alzheimer disease. Arch Neurol. 2007 Jan;64(1):93-6. doi: 10.1001/archneur.64.1.93.
Reddy OC, van der Werf YD The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices. Brain Sci. 2020 Nov 17;10(11):868. doi: 10.3390/brainsci10110868.
Sato N, Morishita R The roles of lipid and glucose metabolism in modulation of beta-amyloid, tau, and neurodegeneration in the pathogenesis of Alzheimer disease. Front Aging Neurosci. 2015 Oct 23;7:199. doi: 10.3389/fnagi.2015.00199. eCollection 2015.
Seals DR, Justice JN, LaRocca TJ Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity. J Physiol. 2016 Apr 15;594(8):2001-24. doi: 10.1113/jphysiol.2014.282665. Epub 2015 Mar 11.
Seals DR, Melov S Translational geroscience: emphasizing function to achieve optimal longevity. Aging (Albany NY). 2014 Sep;6(9):718-30. doi: 10.18632/aging.100694.
Settembre C, Ballabio A Cell metabolism: autophagy transcribed. Nature. 2014 Dec 4;516(7529):40-1. doi: 10.1038/nature13939. Epub 2014 Nov 12. No abstract available.
Shin D, Kongpakpaisarn K, Bohra C Trends in the prevalence of metabolic syndrome and its components in the United States 2007-2014. Int J Cardiol. 2018 May 15;259:216-219. doi: 10.1016/j.ijcard.2018.01.139. Epub 2018 Feb 19.
Sims-Robinson C, Kim B, Rosko A, Feldman EL How does diabetes accelerate Alzheimer disease pathology? Nat Rev Neurol. 2010 Oct;6(10):551-9. doi: 10.1038/nrneurol.2010.130. Epub 2010 Sep 14.
Wang C, Holtzman DM Bidirectional relationship between sleep and Alzheimer's disease: role of amyloid, tau, and other factors. Neuropsychopharmacology. 2020 Jan;45(1):104-120. doi: 10.1038/s41386-019-0478-5. Epub 2019 Aug 13.
Ware J Jr, Kosinski M, Keller SD A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. Med Care. 1996 Mar;34(3):220-33. doi: 10.1097/00005650-199603000-00003.
Wieckowska-Gacek A, Mietelska-Porowska A, Wydrych M, Wojda U Western diet as a trigger of Alzheimer's disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration. Ageing Res Rev. 2021 Sep;70:101397. doi: 10.1016/j.arr.2021.101397. Epub 2021 Jun 30.
Woodie LN, Neinast CE, Haynes W, Ahmed B, Graff EC, Greene MW The physio-metabolic effects of time-restricting liquid sugar intake to six-hour windows during the mouse active phase: The effects of active phase liquid sugar consumption. Physiol Behav. 2020 Sep 1;223:112905. doi: 10.1016/j.physbeh.2020.112905. Epub 2020 May 22.
Zhang F, Liu L, Zhang C, Ji S, Mei Z, Li T Association of Metabolic Syndrome and Its Components With Risk of Stroke Recurrence and Mortality: A Meta-analysis. Neurology. 2021 Aug 17;97(7):e695-e705. doi: 10.1212/WNL.0000000000012415. Epub 2021 Jul 28.
Fasting to Provide Energy Needed to Help Adults in Need of Cognitive Enhancement (FASTING ENHANCE)
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.