Alveolar Bone Loss — Treatment of Alveolar Bone Defects Using Aastrom Biosciences Autologous Tissue Repair Cell Therapy
Citation(s)
Albrektsson T, Brånemark PI, Hansson HA, Lindström J Osseointegrated titanium implants. Requirements for ensuring a long-lasting, direct bone-to-implant anchorage in man. Acta Orthop Scand. 1981;52(2):155-70.
Albrektsson T, Lekholm U Osseointegration: current state of the art. Dent Clin North Am. 1989 Oct;33(4):537-54. Review.
Amler MH The time sequence of tissue regeneration in human extraction wounds. Oral Surg Oral Med Oral Pathol. 1969 Mar;27(3):309-18.
Atwood DA, Coy WA Clinical, cephalometric, and densitometric study of reduction of residual ridges. J Prosthet Dent. 1971 Sep;26(3):280-95.
Atwood DA Reduction of residual ridges: a major oral disease entity. J Prosthet Dent. 1971 Sep;26(3):266-79.
Caldwell J, Palsson BO, Locey B, Emerson SG Culture perfusion schedules influence the metabolic activity and granulocyte-macrophage colony-stimulating factor production rates of human bone marrow stromal cells. J Cell Physiol. 1991 May;147(2):344-53.
Cardaropoli G, Araújo M, Hayacibara R, Sukekava F, Lindhe J Healing of extraction sockets and surgically produced - augmented and non-augmented - defects in the alveolar ridge. An experimental study in the dog. J Clin Periodontol. 2005 May;32(5):435-40.
Cardaropoli G, Araújo M, Lindhe J Dynamics of bone tissue formation in tooth extraction sites. An experimental study in dogs. J Clin Periodontol. 2003 Sep;30(9):809-18.
Cochran D Implant therapy I. Ann Periodontol. 1996 Nov;1(1):707-91. Review.
Colter DC, Class R, DiGirolamo CM, Prockop DJ Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3213-8.
De Kok IJ, Drapeau SJ, Young R, Cooper LF Evaluation of mesenchymal stem cells following implantation in alveolar sockets: a canine safety study. Int J Oral Maxillofac Implants. 2005 Jul-Aug;20(4):511-8.
Fugazzotto PA Success and failure rates of osseointegrated implants in function in regenerated bone for 72 to 133 months. Int J Oral Maxillofac Implants. 2005 Jan-Feb;20(1):77-83.
Marei MK, Nouh SR, Saad MM, Ismail NS Preservation and regeneration of alveolar bone by tissue-engineered implants. Tissue Eng. 2005 May-Jun;11(5-6):751-67.
Misch CE Bone classification, training keys to implant success. Dent Today. 1989 May;8(4):39-44.
Schenk RK, Buser D, Hardwick WR, Dahlin C Healing pattern of bone regeneration in membrane-protected defects: a histologic study in the canine mandible. Int J Oral Maxillofac Implants. 1994 Jan-Feb;9(1):13-29.
Schropp L, Wenzel A, Kostopoulos L, Karring T Bone healing and soft tissue contour changes following single-tooth extraction: a clinical and radiographic 12-month prospective study. Int J Periodontics Restorative Dent. 2003 Aug;23(4):313-23.
Schwartz RM, Palsson BO, Emerson SG Rapid medium perfusion rate significantly increases the productivity and longevity of human bone marrow cultures. Proc Natl Acad Sci U S A. 1991 Aug 1;88(15):6760-4.
Shang Q, Wang Z, Liu W, Shi Y, Cui L, Cao Y Tissue-engineered bone repair of sheep cranial defects with autologous bone marrow stromal cells. J Craniofac Surg. 2001 Nov;12(6):586-93; discussion 594-5.
Stanford CM Bone quantity and quality: are they relevant predictors of implant outcomes? Int J Prosthodont. 2003;16 Suppl:43-5; discussion 47-51. Review.
Wang Z, Song J, Taichman RS, Krebsbach PH Ablation of proliferating marrow with 5-fluorouracil allows partial purification of mesenchymal stem cells. Stem Cells. 2006 Jun;24(6):1573-82.
Wenzel A Bitewing and digital bitewing radiography for detection of caries lesions. J Dent Res. 2004;83 Spec No C:C72-5. Review.
Treatment of Alveolar Bone Defects Using Aastrom Biosciences Autologous Tissue Repair Cell Therapy
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
