NCT04998058 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Boeckel DG, Sesterheim P, Peres TR, Augustin AH, Wartchow KM, Machado DC, Fritscher GG, Teixeira ER
Adipogenic Mesenchymal Stem Cells and Hyaluronic Acid as a Cellular Compound for Bone Tissue Engineering. J Craniofac Surg. 2019 May/Jun;30(3):777-783. doi: 10.1097/SCS.0000000000005392.
Cabreira CL, Fulginiti RL, Sesterheim P, Shinkai RSA, Teixeira ER
Effect of hyaluronic acid on paracrine signaling of osteoblasts from mesenchymal stromal cells: potential impact on bone regeneration. Clin Oral Investig. 2021 Jul;25(7):4571-4578. doi: 10
Teixeira ER, Boeckel D, Fulginiti R L, Shinkai R S A, Machado D
Mesenchymal stem cells and hyaluronic acid for bone grafting. Clinical Oral Implants Research, 2018, (29), 55-55.

Autogenous Mesenchymal Stem Cell Culture-Derived Signalling Molecules as Enhancers of Bone Formation in Bone Grafting

Clinical trial NCT04998058 - References