Beever R Far-infrared saunas for treatment of cardiovascular risk factors: summary of published evidence. Can Fam Physician. 2009 Jul;55(7):691-6. Review.
Chang Y, Liu YP, Liu CF The effect on serotonin and MDA levels in depressed patients with insomnia when far-infrared rays are applied to acupoints. Am J Chin Med. 2009;37(5):837-42.
Cheng KJ, Xu YY, Liu HY, Wang SQ Serum eosinophil cationic protein level in Chinese subjects with nonallergic and local allergic rhinitis and its relation to the severity of disease. Am J Rhinol Allergy. 2013 Jan;27(1):8-12. doi: 10.2500/ajra.2013.27.384
Davis WE, Nishioka GJ Endoscopic partial inferior turbinectomy using a power microcutting instrument. Ear Nose Throat J. 1996 Jan;75(1):49-50.
Honda K, Inoué S Sleep-enhancing effects of far-infrared radiation in rats. Int J Biometeorol. 1988 Jun;32(2):92-4.
Hu KH, Li WT Clinical effects of far-infrared therapy in patients with allergic rhinitis. Conf Proc IEEE Eng Med Biol Soc. 2007;2007:1479-82.
Huang CY, Yang RS, Kuo TS, Hsu KH Phantom limb pain treated by far infrared ray. Conf Proc IEEE Eng Med Biol Soc. 2009;2009:1589-91. doi: 10.1109/IEMBS.2009.5334124.
Juniper EF, Guyatt GH, Dolovich J Assessment of quality of life in adolescents with allergic rhinoconjunctivitis: development and testing of a questionnaire for clinical trials. J Allergy Clin Immunol. 1994 Feb;93(2):413-23.
Lin CC, Chiang YS, Lung CC Effect of infrared-C radiation on skin temperature, electrodermal conductance and pain in hemiparetic stroke patients. Int J Radiat Biol. 2015 Jan;91(1):42-53. doi: 10.3109/09553002.2014.937512. Epub 2014 Aug 11.
Luo H, Zhang J, Yu Y, Liu J, Jiang Y, Yan N, Wang P, Kong W [Relationship between eosinophils in nasal discharge and responses to treatment of inhaled glucocorticosteroid in patients with persistent allergic rhinitis]. Lin Chung Er Bi Yan Hou Tou Jing Wa
Marciniak D, Tomaszewicz-Fryca J, Plusa T, Chcialowski A [Eosinophil cationic protein in children with allergic diseases of the respiratory tract in exacerbation and remission of symptoms]. Pol Merkur Lekarski. 1998 Feb;4(20):75-7. Polish.
Masuda A, Munemoto T, Tei C [A new treatment: thermal therapy for chronic fatigue syndrome]. Nihon Rinsho. 2007 Jun;65(6):1093-8. Review. Japanese.
Sin A, Terzioglu E, Kokuludag A, Sebik F, Kabakçi T Serum eosinophil cationic protein (ECP) levels in patients with seasonal allergic rhinitis and allergic asthma. Allergy Asthma Proc. 1998 Mar-Apr;19(2):69-73.
Ware JE Jr, Sherbourne CD The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992 Jun;30(6):473-83.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
