Baser O, Chalk M, Rawson R, Gastfriend DR Alcohol dependence treatments: comprehensive healthcare costs, utilization outcomes, and pharmacotherapy persistence. Am J Manag Care. 2011 Jun;17 Suppl 8:S222-34.
Bray JW, Cowell AJ, Hinde JM A systematic review and meta-analysis of health care utilization outcomes in alcohol screening and brief intervention trials. Med Care. 2011 Mar;49(3):287-94. doi: 10.1097/MLR.0b013e318203624f. Review.
Cohen E, Feinn R, Arias A, Kranzler HR Alcohol treatment utilization: findings from the National Epidemiologic Survey on Alcohol and Related Conditions. Drug Alcohol Depend. 2007 Jan 12;86(2-3):214-21. Epub 2006 Aug 17.
Compton WM, Thomas YF, Stinson FS, Grant BF Prevalence, correlates, disability, and comorbidity of DSM-IV drug abuse and dependence in the United States: results from the national epidemiologic survey on alcohol and related conditions. Arch Gen Psychiatry. 2007 May;64(5):566-76.
Corrao G, Bagnardi V, Zambon A, Arico S Exploring the dose-response relationship between alcohol consumption and the risk of several alcohol-related conditions: a meta-analysis. Addiction. 1999 Oct;94(10):1551-73.
Gual A, Bravo F, Lligoña A, Colom J Treatment for alcohol dependence in Catalonia: health outcomes and stability of drinking patterns over 20 years in 850 patients. Alcohol Alcohol. 2009 Jul-Aug;44(4):409-15. doi: 10.1093/alcalc/agp032. Epub 2009 Jun 2.
Gual A, Lligoña A, Costa S, Segura L, Colom J [Long term impact of treatment in alcoholics. Results from a 10-year longitudinal follow-up study of 850 patients]. Med Clin (Barc). 2004 Sep 25;123(10):364-9. Spanish.
Lawder R, Grant I, Storey C, Walsh D, Whyte B, Hanlon P Epidemiology of hospitalization due to alcohol-related harm: evidence from a Scottish cohort study. Public Health. 2011 Aug;125(8):533-9. doi: 10.1016/j.puhe.2011.05.007. Epub 2011 Jul 26.
McKenny M, O'Beirne S, Fagan C, O'Connell M Alcohol-related admissions to an intensive care unit in Dublin. Ir J Med Sci. 2010 Sep;179(3):405-8. doi: 10.1007/s11845-010-0498-y. Epub 2010 May 28.
Rehm J, Giesbrecht N, Patra J, Roerecke M Estimating chronic disease deaths and hospitalizations due to alcohol use in Canada in 2002: implications for policy and prevention strategies. Prev Chronic Dis. 2006 Oct;3(4):A121. Epub 2006 Sep 15.
Taylor B, Rehm J, Patra J, Popova S, Baliunas D Alcohol-attributable morbidity and resulting health care costs in Canada in 2002: recommendations for policy and prevention. J Stud Alcohol Drugs. 2007 Jan;68(1):36-47.
Impact of Alcohol Consumption of the General Population Who Visited Primary Health Care Centers on the Use of Health Care Resources in Catalonia.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
