NCT00487838 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Klein R, Klein BE, Linton KL
Prevalence of age-related maculopathy. The Beaver Dam Eye Study. Ophthalmology. 1992 Jun;99(6):933-43.
Taylor HR, West S, Muñoz B, Rosenthal FS, Bressler SB, Bressler NM
The long-term effects of visible light on the eye. Arch Ophthalmol. 1992 Jan;110(1):99-104.
Tomany SC, Cruickshanks KJ, Klein R, Klein BE, Knudtson MD
Sunlight and the 10-year incidence of age-related maculopathy: the Beaver Dam Eye Study. Arch Ophthalmol. 2004 May;122(5):750-7. Erratum in: Arch Ophthalmol. 2005 Mar;123(3):362.

Noninvasive Optical Imaging of the Effects of External Spectral Filters on Macular Autofluorescence in Pseudophakic Eyes

Clinical trial NCT00487838 - References