Clinical trial NCT04531579 - References

Acute Kidney Injury — Valproic Acid (VPA) for Acute Kidney Injury (AKI) in Trauma Patients

Citation(s)

•   Bihorac A, Delano MJ, Schold JD, Lopez MC, Nathens AB, Maier RV, Layon AJ, Baker HV, Moldawer LL
  Incidence, clinical predictors, genomics, and outcome of acute kidney injury among trauma patients. Ann Surg. 2010 Jul;252(1):158-65. doi: 10.1097/SLA.0b013e3181deb6bc.
•   Chateauvieux S, Morceau F, Dicato M, Diederich M
  Molecular and therapeutic potential and toxicity of valproic acid. J Biomed Biotechnol. 2010;2010. pii: 479364. doi: 10.1155/2010/479364. Epub 2010 Jul 29. Review.
•   Costantini TW, Fraga G, Fortlage D, Wynn S, Fraga A, Lee J, Doucet J, Bansal V, Coimbra R
  Redefining renal dysfunction in trauma: implementation of the Acute Kidney Injury Network staging system. J Trauma. 2009 Aug;67(2):283-7; discussion 287-8. doi: 10.1097/TA.0b013e3181a51a51.
•   Georgoff PE, Nikolian VC, Bonham T, Pai MP, Tafatia C, Halaweish I, To K, Watcharotone K, Parameswaran A, Luo R, Sun D, Alam HB
  Safety and Tolerability of Intravenous Valproic Acid in Healthy Subjects: A Phase I Dose-Escalation Trial. Clin Pharmacokinet. 2018 Feb;57(2):209-219. doi: 10.1007/s40262-017-0553-1.
•   Heegard KD, Stewart IJ, Cap AP, Sosnov JA, Kwan HK, Glass KR, Morrow BD, Latack W, Henderson AT, Saenz KK, Siew ED, Ikizler TA, Chung KK
  Early acute kidney injury in military casualties. J Trauma Acute Care Surg. 2015 May;78(5):988-93. doi: 10.1097/TA.0000000000000607.
•   Li Y, Alam HB
  Creating a pro-survival and anti-inflammatory phenotype by modulation of acetylation in models of hemorrhagic and septic shock. Adv Exp Med Biol. 2012;710:107-33. doi: 10.1007/978-1-4419-5638-5_11.
•   Wu MY, Yiang GT, Liao WT, Tsai AP, Cheng YL, Cheng PW, Li CY, Li CJ
  Current Mechanistic Concepts in Ischemia and Reperfusion Injury. Cell Physiol Biochem. 2018;46(4):1650-1667. doi: 10.1159/000489241. Epub 2018 Apr 20. Review.
•   Zheng Q, Liu W, Liu Z, Zhao H, Han X, Zhao M
  Valproic acid protects septic mice from renal injury by reducing the inflammatory response. J Surg Res. 2014 Nov;192(1):163-9. doi: 10.1016/j.jss.2014.05.030. Epub 2014 May 20.

Evaluation of Valproic Acid (VPA) as Adjunctive Therapy for Trauma Patients With Moderate to Severe Hemorrhage at Risk of Ischemia Reperfusion (I/R) Injury

Details for clinical trial NCT04531579