Acute Ischemic Stroke — Biologic Mechanisms of Early Exercise After Intracerebral Hemorrhage
Citation(s)
Amidei C, Sole ML Physiological responses to passive exercise in adults receiving mechanical ventilation. Am J Crit Care. 2013 Jul;22(4):337-48. doi: 10.4037/ajcc2013284.
Arafah BM, Nishiyama FJ, Tlaygeh H, Hejal R Measurement of salivary cortisol concentration in the assessment of adrenal function in critically ill subjects: a surrogate marker of the circulating free cortisol. J Clin Endocrinol Metab. 2007 Aug;92(8):2965-71. doi: 10.1210/jc.2007-0181. Epub 2007 May 29.
Burn JP Reliability of the modified Rankin Scale. Stroke. 1992 Mar;23(3):438. No abstract available.
Calabrese EJ Pre- and post-conditioning hormesis in elderly mice, rats, and humans: its loss and restoration. Biogerontology. 2016 Aug;17(4):681-702. doi: 10.1007/s10522-016-9646-8. Epub 2016 Apr 13.
Chen J, Qin J, Su Q, Liu Z, Yang J Treadmill rehabilitation treatment enhanced BDNF-TrkB but not NGF-TrkA signaling in a mouse intracerebral hemorrhage model. Neurosci Lett. 2012 Oct 31;529(1):28-32. doi: 10.1016/j.neulet.2012.09.021. Epub 2012 Sep 19.
Cocks K, Torgerson DJ Sample size calculations for pilot randomized trials: a confidence interval approach. J Clin Epidemiol. 2013 Feb;66(2):197-201. doi: 10.1016/j.jclinepi.2012.09.002. Epub 2012 Nov 27.
Duffy L, Gajree S, Langhorne P, Stott DJ, Quinn TJ Reliability (inter-rater agreement) of the Barthel Index for assessment of stroke survivors: systematic review and meta-analysis. Stroke. 2013 Feb;44(2):462-8. doi: 10.1161/STROKEAHA.112.678615. Epub 2013 Jan 8.
Fogelholm R, Murros K, Rissanen A, Avikainen S Long term survival after primary intracerebral haemorrhage: a retrospective population based study. J Neurol Neurosurg Psychiatry. 2005 Nov;76(11):1534-8. doi: 10.1136/jnnp.2004.055145.
Giraldo E, Garcia JJ, Hinchado MD, Ortega E Exercise intensity-dependent changes in the inflammatory response in sedentary women: role of neuroendocrine parameters in the neutrophil phagocytic process and the pro-/anti-inflammatory cytokine balance. Neuroimmunomodulation. 2009;16(4):237-44. doi: 10.1159/000212384. Epub 2009 Apr 9.
Gomez-Cabrera MC, Domenech E, Vina J Moderate exercise is an antioxidant: upregulation of antioxidant genes by training. Free Radic Biol Med. 2008 Jan 15;44(2):126-31. doi: 10.1016/j.freeradbiomed.2007.02.001. Epub 2007 Feb 9.
Guo YC, Song XK, Xu YF, Ma JB, Zhang JJ, Han PJ The expression and mechanism of BDNF and NGB in perihematomal tissue in rats with intracerebral hemorrhage. Eur Rev Med Pharmacol Sci. 2017 Aug;21(15):3452-3458.
Hanley DF Intraventricular hemorrhage: severity factor and treatment target in spontaneous intracerebral hemorrhage. Stroke. 2009 Apr;40(4):1533-8. doi: 10.1161/STROKEAHA.108.535419. Epub 2009 Feb 26.
Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009 Apr;42(2):377-81. doi: 10.1016/j.jbi.2008.08.010. Epub 2008 Sep 30.
Hemphill JC 3rd, Farrant M, Neill TA Jr Prospective validation of the ICH Score for 12-month functional outcome. Neurology. 2009 Oct 6;73(14):1088-94. doi: 10.1212/WNL.0b013e3181b8b332. Epub 2009 Sep 2.
Ji LL, Gomez-Cabrera MC, Vina J Exercise and hormesis: activation of cellular antioxidant signaling pathway. Ann N Y Acad Sci. 2006 May;1067:425-35. doi: 10.1196/annals.1354.061.
Lei C, Lin S, Zhang C, Tao W, Dong W, Hao Z, Liu M, Wu B High-mobility group box1 protein promotes neuroinflammation after intracerebral hemorrhage in rats. Neuroscience. 2013 Jan 3;228:190-9. doi: 10.1016/j.neuroscience.2012.10.023. Epub 2012 Oct 22.
Mendelow AD, Gregson BA, Rowan EN, Murray GD, Gholkar A, Mitchell PM; STICH II Investigators Early surgery versus initial conservative treatment in patients with spontaneous supratentorial lobar intracerebral haematomas (STICH II): a randomised trial. Lancet. 2013 Aug 3;382(9890):397-408. doi: 10.1016/S0140-6736(13)60986-1. Epub 2013 May 29. Erratum In: Lancet. 2013 Aug 3;382(9890):396. Lancet. 2021 Sep 18;398(10305):1042.
Takamatsu Y, Tamakoshi K, Waseda Y, Ishida K Running exercise enhances motor functional recovery with inhibition of dendritic regression in the motor cortex after collagenase-induced intracerebral hemorrhage in rats. Behav Brain Res. 2016 Mar 1;300:56-64. doi: 10.1016/j.bbr.2015.12.003. Epub 2015 Dec 7.
Teasdale G, Jennett B Assessment of coma and impaired consciousness. A practical scale. Lancet. 1974 Jul 13;2(7872):81-4. doi: 10.1016/s0140-6736(74)91639-0. No abstract available.
Thelandersson A, Nellgard B, Ricksten SE, Cider A Effects of Early Bedside Cycle Exercise on Intracranial Pressure and Systemic Hemodynamics in Critically Ill Patients in a Neurointensive Care Unit. Neurocrit Care. 2016 Dec;25(3):434-439. doi: 10.1007/s12028-016-0278-2.
Wang P, Li CG, Qi Z, Cui D, Ding S Acute exercise stress promotes Ref1/Nrf2 signalling and increases mitochondrial antioxidant activity in skeletal muscle. Exp Physiol. 2016 Mar;101(3):410-20. doi: 10.1113/EP085493. Epub 2016 Jan 23.
Wei P, You C, Jin H, Chen H, Lin B Correlation between serum IL-1beta levels and cerebral edema extent in a hypertensive intracerebral hemorrhage rat model. Neurol Res. 2014 Feb;36(2):170-5. doi: 10.1179/1743132813Y.0000000292. Epub 2013 Dec 19.
Winkelman C Investigating activity in hospitalized patients with chronic obstructive pulmonary disease: a pilot study. Heart Lung. 2010 Jul-Aug;39(4):319-30. doi: 10.1016/j.hrtlng.2009.09.004. Epub 2010 Apr 8.
Wu J, Yang S, Xi G, Song S, Fu G, Keep RF, Hua Y Microglial activation and brain injury after intracerebral hemorrhage. Acta Neurochir Suppl. 2008;105:59-65. doi: 10.1007/978-3-211-09469-3_13.
Xue M, Del Bigio MR Comparison of brain cell death and inflammatory reaction in three models of intracerebral hemorrhage in adult rats. J Stroke Cerebrovasc Dis. 2003 May-Jun;12(3):152-9. doi: 10.1016/S1052-3057(03)00036-3.
Yang X, Ren W, Zu H, Dong Q Evaluate the serum cortisol in patients with intracerebral hemorrhage. Clin Neurol Neurosurg. 2014 Aug;123:127-30. doi: 10.1016/j.clineuro.2014.05.019. Epub 2014 Jun 5.
Yang Z, Yu A, Liu Y, Shen H, Lin C, Lin L, Wang S, Yuan B Regulatory T cells inhibit microglia activation and protect against inflammatory injury in intracerebral hemorrhage. Int Immunopharmacol. 2014 Oct;22(2):522-5. doi: 10.1016/j.intimp.2014.06.037. Epub 2014 Jul 4.
Yong MS, Hwangbo K Skilled reach training influences brain recovery following intracerebral hemorrhage in rats. J Phys Ther Sci. 2014 Mar;26(3):405-7. doi: 10.1589/jpts.26.405. Epub 2014 Mar 25.
Yuan ZH, Jiang JK, Huang WD, Pan J, Zhu JY, Wang JZ A meta-analysis of the efficacy and safety of recombinant activated factor VII for patients with acute intracerebral hemorrhage without hemophilia. J Clin Neurosci. 2010 Jun;17(6):685-93. doi: 10.1016/j.jocn.2009.11.020.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.