Acute Abdomen — Different Fluidic Strategy in Patients With Acute Abdomen : The Sure Volume
Citation(s)
Cotton BA, Guy JS, Morris JA Jr, Abumrad NN The cellular, metabolic, and systemic consequences of aggressive fluid resuscitation strategies. Shock. 2006 Aug;26(2):115-21. Review.
Madigan MC, Kemp CD, Johnson JC, Cotton BA Secondary abdominal compartment syndrome after severe extremity injury: are early, aggressive fluid resuscitation strategies to blame? J Trauma. 2008 Feb;64(2):280-5. doi: 10.1097/TA.0b013e3181622bb6.
Marshall JC, Innes M Intensive care unit management of intra-abdominal infection. Crit Care Med. 2003 Aug;31(8):2228-37. Review.
Stafford RE, Weigelt JA Surgical infections in the critically ill. Curr Opin Crit Care. 2002 Oct;8(5):449-52. Review.
Streat SJ, Plank LD, Hill GL Overview of modern management of patients with critical injury and severe sepsis. World J Surg. 2000 Jun;24(6):655-63. Review.
MANAGEMENT OF THE PATIENT WITH ACUTE ABDOMEN SUBMITTED TO URGENT ABDOMINAL SURGERY: a Pilot Randomized Multicentre Study
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
