ACL Injury — Neuromuscular Training Improves Single-Limb Stability
Citation(s)
Bonci CM Assessment and evaluation of predisposing factors to anterior cruciate ligament injury. J Athl Train. 1999 Apr;34(2):155-64.
Chappell JD, Limpisvasti O Effect of a neuromuscular training program on the kinetics and kinematics of jumping tasks. Am J Sports Med. 2008 Jun;36(6):1081-6. doi: 10.1177/0363546508314425. Epub 2008 Mar 21.
Etty Griffin LY Neuromuscular training and injury prevention in sports. Clin Orthop Relat Res. 2003 Apr;(409):53-60. Review.
Gianotti SM, Marshall SW, Hume PA, Bunt L Incidence of anterior cruciate ligament injury and other knee ligament injuries: a national population-based study. J Sci Med Sport. 2009 Nov;12(6):622-7. doi: 10.1016/j.jsams.2008.07.005. Epub 2008 Oct 2.
Hewett TE, Ford KR, Myer GD Anterior cruciate ligament injuries in female athletes: Part 2, a meta-analysis of neuromuscular interventions aimed at injury prevention. Am J Sports Med. 2006 Mar;34(3):490-8. Epub 2005 Dec 28.
Hewett TE, Lindenfeld TN, Riccobene JV, Noyes FR The effect of neuromuscular training on the incidence of knee injury in female athletes. A prospective study. Am J Sports Med. 1999 Nov-Dec;27(6):699-706.
Ireland ML Anterior cruciate ligament injury in female athletes: epidemiology. J Athl Train. 1999 Apr;34(2):150-4.
McLeod TC, Armstrong T, Miller M, Sauers JL Balance improvements in female high school basketball players after a 6-week neuromuscular-training program. J Sport Rehabil. 2009 Nov;18(4):465-81.
Myer GD, Ford KR, Brent JL, Hewett TE Differential neuromuscular training effects on ACL injury risk factors in"high-risk" versus "low-risk" athletes. BMC Musculoskelet Disord. 2007 May 8;8:39.
Myer GD, Sugimoto D, Thomas S, Hewett TE The influence of age on the effectiveness of neuromuscular training to reduce anterior cruciate ligament injury in female athletes: a meta-analysis. Am J Sports Med. 2013 Jan;41(1):203-15. doi: 10.1177/0363546512460637. Epub 2012 Oct 9. Review.
Richmond SA, Kang J, Doyle-Baker PK, Nettel-Aguirre A, Emery CA A School-Based Injury Prevention Program to Reduce Sport Injury Risk and Improve Healthy Outcomes in Youth: A Pilot Cluster-Randomized Controlled Trial. Clin J Sport Med. 2016 Jul;26(4):291-8. doi: 10.1097/JSM.0000000000000261.
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