NCT03480009 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

American College of Obstetricians and Gynecologists
Practice bulletin no. 143: medical management of first-trimester abortion. Obstet Gynecol. 2014 Mar;123(3):676-92. doi: 10.1097/01.AOG.0000444454.67279.7d.
Christie A, Dagfinrud H, Dale Ø, Schulz T, Hagen KB
Collection of patient-reported outcomes;--text messages on mobile phones provide valid scores and high response rates. BMC Med Res Methodol. 2014 Apr 16;14:52. doi: 10.1186/1471-2288-14-52.
Ilkjaer S, Nielsen PA, Bach LF, Wernberg M, Dahl JB
The effect of dextromethorphan, alone or in combination with ibuprofen, on postoperative pain after minor gynaecological surgery. Acta Anaesthesiol Scand. 2000 Aug;44(7):873-7.
Penney G
Treatment of pain during medical abortion. Contraception. 2006 Jul;74(1):45-7. Epub 2006 May 6. Review.
Weinbroum AA, Rudick V, Paret G, Ben-Abraham R
The role of dextromethorphan in pain control. Can J Anaesth. 2000 Jun;47(6):585-96. Review.

Dextromethorphan as a Novel Non-opioid Adjunctive Agent for Pain Control in Medication Abortion: a Randomized Controlled Trial

Clinical trial NCT03480009 - References