Aloe Vera Versus Thyme Honey Mouthwash in Management of Xerostomia in Type

Status Active, not recruiting

Clinical Trial Summary

The objectives of the present study are to: 1. Compare the clinical efficacy of (50%) aloe vera versus (20%) thyme honey mouthwash on management of xerostomia in diabetic patients by measuring the salivary flow rate as a primary objective. 2. Asses the biochemical effect of aloe vera and thyme honey on the level of salivary nitric oxide, xerostomia grade as well as patient quality of life as a secondary objective. Research question: Which is better aloe vera or thyme honey in improving salivary flow rate in diabetic patients suffering from xerostomia? Patient Grouping and Randomization: Patients with xerostomia will be randomly distributed into three groups using a computer-generated randomization table. Allocation concealment will be achieved by a sealed opaque envelope with a ratio of 1:1:1 Group 1 (Aloe Vera group) Include (15) patient suffering from diabetes induced xerostomia that will receive aloe vera as mouthwash Group 2 (Thyme honey group): Include (15) patient suffering from diabetes induced xerostomia that will receive thyme honey mouthwash Group 3 (Saline control group): Include (15) patient suffering from diabetes induced xerostomia that will receive saline mouthwash

Clinical Trial Description

Saliva is a complex mix from major as well as minor salivary glands and gingival crevicular fluids. It is a clear and slightly acidic diluted secretion with more than 99% water, electrolytes, immunoglobulins, enzymes, proteins, mucin and nitrogenous products. Subjective feeling of a dry mouth is known as xerostomia, which may result from diminished saliva production, but some people reported feeling a dry mouth even though there was no decrease in saliva quantity.Diabetes mellitus is considered one of the main causes of xerostomia There are different treatments modalities of xerostomia which include pharmacological and non-pharmacological treatments.Recently different herbs were used in the treatment of xerostomia and showed promising results and great patient acceptance among which aloe vera and thyme honey are used. ;

Study Design

Related Conditions & MeSH terms

Xerostomia

Clinical Trial Details

NCT number	NCT05885906
Study type	Interventional
Source	Ain Shams University
Contact
Status	Active, not recruiting
Phase	Phase 3
Start date	July 24, 2023
Completion date	March 2024

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05342272` - Comparison of Gum® HydralTM Moisturizing Gel and Biotene® Oral Gel in Dry Mouth Sensation Reduction	Phase 3
Completed	`NCT03302676` - The Use of Chewing Gum for Xerostomia and Hyposalivation After Radiotherapy for Oral and Oropharyngeal Tumors	N/A
Completed	`NCT02375451` - Effect of Childhood Radioiodine Therapy on Salivary Function	N/A
Completed	`NCT01272570` - Oral Health and Oral Health-Related Quality of Life in Early Stage Breast Cancer Survivors	N/A
Completed	`NCT00656513` - Acupuncture-Like Transcutaneous Electrical Nerve Stimulation (ALTENS) or Pilocarpine in Treating Early Dry Mouth in Patients Undergoing Radiation Therapy for Head and Neck Cancer	Phase 2/Phase 3
Completed	`NCT00911768` - Effect of Korean Red Ginseng (KRG) on Dry Mouth	Phase 4
Completed	`NCT00332618` - Efficacy Study of Oxygenated Glycerol Triesters to Treat Xerostomia	Phase 2
Completed	`NCT03494985` - A Clinical Study to Evaluate the Efficacy of Three Dry Mouth Relief Products Versus Water	N/A
Completed	`NCT05058430` - SaliPen Human Factors Study for OTC Labeling	N/A
Recruiting	`NCT02705937` - Early Phase Study Comparing the Effectiveness of a Dairy Product With the Reference Treatment Aequasyal® on Dry Mouth Symptoms in Patients Suffering From Xerostomia Caused by Psychotropic Medications.	N/A
Completed	`NCT05247008` - Effectiveness of Thyme Honey in Management of Xerostomia in ESRD	N/A
Recruiting	`NCT03632096` - Photobiomodulation in Salivary Production of Patients With Xerostomy	Phase 2
Not yet recruiting	`NCT04323384` - The Effect of Biotene® on the Symptoms of Xerostomia and Mastication and Swallowing	N/A
Not yet recruiting	`NCT03530735` - Finger-prick Autologous Blood (FAB) for Use in Dry Mouth	N/A
Active, not recruiting	`NCT03176368` - Coconut Oil: Managing Radiation-Induced Xerostomia	N/A
Enrolling by invitation	`NCT06122636` - Efficacy of a Probiotic and Microbiological Analysis on Oral Complications Induced by Antineoplastic Therapies in Patients With HNC	N/A
Completed	`NCT03611283` - Topical Management of Xerostomia With Dry Mouth Products	N/A
Completed	`NCT02682199` - Prospective Evaluation of Patient Reported Xerostomia After Whole Brain Radiation
Withdrawn	`NCT01960101` - Development of a Milk Product Substitution for Patients Suffering From Xerostomia Caused by Medication	N/A
Completed	`NCT02317172` - Efficacy of Novel Edible Gel-based Artificial Saliva in Thai Geriatric Populations With Systemic Diseases	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Aloe Vera Versus Thyme Honey Mouthwash in Management of Xerostomia in Type 2 Diabetics

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms