Xerosis Cutis Clinical Trial
Official title:
Effectiveness and Safety Comparison Between Moisturizers Containing Low Molecular Weight Hyaluronic Acid, High Molecular Weight Hyaluronic Acid, and Vehicle on Skin Hydration in the Elderly With Xerotic Skin
Verified date | April 2024 |
Source | Indonesia University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The goal of this clinical trial is to compare 0,1% topical low molecular weight (7 kDa) hyaluronic acid with 0,1% high molecular weight (1.800 kDa) hyaluronic acid as therapy of xerotic skin in elderly
Status | Completed |
Enrollment | 36 |
Est. completion date | September 30, 2023 |
Est. primary completion date | September 30, 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 60 Years to 80 Years |
Eligibility | Inclusion Criteria: - Female or male diagnosed with xerotic skin - 60-80 years old - Willing to participate in clinical trial and sign informed consent Exclusion Criteria: - History of hypersensitivity to moisturizer - Dermatitis or any dermatosis on intervention area in the leg - Score of erythema and crack more than 2, based on SRRC scoring |
Country | Name | City | State |
---|---|---|---|
Indonesia | Panti Sosial Tresna Werdha Budi Mulia 3 | Jakarta | DKI Jakarta |
Lead Sponsor | Collaborator |
---|---|
Indonesia University |
Indonesia,
Ha NG, Lee SH, Lee EH, Chang M, Yoo J, Lee WJ. Safety and efficacy of a new hydrogel based on hyaluronic acid as cosmeceutical for xerosis. J Cosmet Dermatol. 2022 Dec;21(12):6840-6849. doi: 10.1111/jocd.15368. Epub 2022 Sep 20. — View Citation
Pavicic T, Gauglitz GG, Lersch P, Schwach-Abdellaoui K, Malle B, Korting HC, Farwick M. Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. J Drugs Dermatol. 2011 Sep;10(9):990-1000. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Skin capacitance | Skin capacitance is measured by Corneometer CM825 | 2 weeks and 4 weeks | |
Primary | Transepidermal water loss | Transepidermal water loss is measured by Tewameter TM300 | 2 weeks and 4 weeks | |
Primary | Specified symptom sum score/scale, roughness, redness, crack (SRRC) | Evaluation of squama/scale, roughness, redness, and crack of the skin, with a value range of 0-16. Higher values mean worse outcome | 2 weeks and 4 weeks |
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