Wounds and Injuries Clinical Trial
Official title:
Wound Bacterial Microbiota and Their Antibiotic Resistance: a Prospective Cohort Study of Hospitalized Patients Originating From the Syrian Armed Conflict
Verified date | May 2017 |
Source | Karolinska Institutet |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The purpose of the study is to explore the microbiology in war-associated wounds of hospitalized patients from the Syrian armed conflict. Cultures collected from acute wounds with clinical signs of infection will be analyzed.
Status | Completed |
Enrollment | 457 |
Est. completion date | June 2016 |
Est. primary completion date | June 2016 |
Accepts healthy volunteers | No |
Gender | All |
Age group | N/A and older |
Eligibility |
Inclusion Criteria: - Patients that receive surgical treatment for war-associated injuries, irrespective of injury location, injury mechanism, time from injury and prior treatment - Patients that receive treatment during the study period and are later re-admitted will only be counted as one patient Exclusion Criteria: - Patients that are only re-admitted during the study period, i.e. patients that received primary treatment by MSF before study initiation |
Country | Name | City | State |
---|---|---|---|
Jordan | Ministry of Health hospital | Ar Ramtha | Irbid |
Lead Sponsor | Collaborator |
---|---|
Karolinska Institutet | Medecins Sans Frontieres, Netherlands |
Jordan,
Covey DC, Lurate RB, Hatton CT. Field hospital treatment of blast wounds of the musculoskeletal system during the Yugoslav civil war. J Orthop Trauma. 2000 May;14(4):278-86; discussion 277. — View Citation
Dau AA, Tloba S, Daw MA. Characterization of wound infections among patients injured during the 2011 Libyan conflict. East Mediterr Health J. 2013 Apr;19(4):356-61. — View Citation
Eardley WG, Brown KV, Bonner TJ, Green AD, Clasper JC. Infection in conflict wounded. Philos Trans R Soc Lond B Biol Sci. 2011 Jan 27;366(1562):204-18. doi: 10.1098/rstb.2010.0225. Review. — View Citation
Fares Y, El-Zaatari M, Fares J, Bedrosian N, Yared N. Trauma-related infections due to cluster munitions. J Infect Public Health. 2013 Dec;6(6):482-6. doi: 10.1016/j.jiph.2013.05.006. Epub 2013 Jul 31. — View Citation
Giannou C, Baldan M. War Surgery: Working With Limited Resources in Armed Conflict and Other Situations of Violence. ICRC; 2010.
Murray CK, Hsu JR, Solomkin JS, Keeling JJ, Andersen RC, Ficke JR, Calhoun JH. Prevention and management of infections associated with combat-related extremity injuries. J Trauma. 2008 Mar;64(3 Suppl):S239-51. doi: 10.1097/TA.0b013e318163cd14. Review. — View Citation
Murray CK. Infectious disease complications of combat-related injuries. Crit Care Med. 2008 Jul;36(7 Suppl):S358-64. doi: 10.1097/CCM.0b013e31817e2ffc. Review. — View Citation
Sutter DE, Bradshaw LU, Simkins LH, Summers AM, Atha M, Elwood RL, Robertson JL, Murray CK, Wortmann GW, Hospenthal DR. High incidence of multidrug-resistant gram-negative bacteria recovered from Afghan patients at a deployed US military hospital. Infect Control Hosp Epidemiol. 2011 Sep;32(9):854-60. doi: 10.1086/661284. — View Citation
Teicher CL, Ronat JB, Fakhri RM, Basel M, Labar AS, Herard P, Murphy RA. Antimicrobial drug-resistant bacteria isolated from Syrian war-injured patients, August 2011-March 2013. Emerg Infect Dis. 2014 Nov;20(11):1949-51. doi: 10.3201/eid2011.140835. — View Citation
Tong MJ. Septic complications of war wounds. JAMA. 1972 Feb 21;219(8):1044-7. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Proportion of patients that develops infections after receiving surgical treatment | 30 days | ||
Secondary | Frequency of different bacterial microbiota in wounds with clinical signs of infection | For wounds with clinical signs of infection the bacterial microbiota will be characterized. | 30 days | |
Secondary | Frequency of microbiota with antibiotic resistance in wounds with clinical signs of infection | For wounds with clinical signs of infection the the antibiotic resistance patterns of the bacterial microbiota will be characterized. | 30 days | |
Secondary | Length of stay | Length of hospital stay | 30 days | |
Secondary | Surgery | Number and type of surgeries | 30 days | |
Secondary | Death | Mortality | 30 days |
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