Wounds and Injuries Clinical Trial
Official title:
Evaluation to Determine Whether Transfusion-associated Microchimerism Involves Engraftment With Hematopoietic Progenitor Cells
Individuals who experience traumatic injury often require blood transfusion. In some individuals who receive blood after an injury, white blood cells from a person who donated blood may remain in the body for years, a condition known as microchimerism. This study is designed to examine a group of people who are known to have long-term microchimerism and, through analysis of their blood, determine whether there is evidence that the microchimerism involves blood stem cells that can become any type of blood cell (red blood cells, white blood cells, or platelets) and that might be a permanent part of the body.
Transfusion-associated microchimerism, the persistence of donor white blood cells months or
years after transfusion in the recipient, has been observed in approximately 10-15% of
transfused trauma patients. Previous studies suggest that the microchimeric cells include
multiple immunophenotypes of leukocytes (CD4+, CD8+, CD15+, and CD19+) and that they can
persist for decades, features suggestive of hematopoietic engraftment.
In this study, ten subjects known to have long-term microchimerism will undergo either
leukapheresis (a blood filtering procedure) or collection of a 500 mL whole blood sample
(the amount of a standard blood donation). These samples will then be analyzed to determine
whether the microchimeric (donor) cells include hematopoietic stem cells (CD34+) and
precursor cells in the red blood cell, white blood cell, and platelet lineages.
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Observational Model: Case-Only, Time Perspective: Cross-Sectional
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