Wounds and Injuries Clinical Trial
Official title:
Prospective Study of the Kinetics and Mechanisms of Transfusion-associated Microchimerism in Injured Patients
Individuals who experience a traumatic injury often have a significant amount of blood loss and may require a blood transfusion. In some individuals who receive a blood transfusion, white blood cells from the donor's blood may remain in the body for years, a condition known as microchimerism. This study will examine the reasons why microchimerism occurs in some blood transfusion recipients and not others.
Approximately 20% of individuals who suffer a traumatic injury require a blood transfusion;
of these, 10% to 15% experience a condition known as transfusion-associated microchimerism.
This occurs when white blood cells, or leukocytes, from the donor's blood persist in the
recipient long after the transfusion occurs. The genetically distinct donor cells can remain
in the individual for decades, and may account for as many as 4% of the white blood cells in
the recipient's body. This suggests that the donor cells are tolerated by the recipient's
immune system. The purpose of this study is to examine the specific factors that predispose
some blood transfusion recipients to develop microchimerism.
In this study, blood samples will be collected from injured individuals who arrive at the
University of California at Davis Medical Center. Individuals who receive a blood
transfusion, as well as a control group of individuals who do not receive a transfusion,
will be approached to enroll in the study. Individuals who agree to participate will have
their blood collected at Days 7, 14, and 28 and Months 3 and 6. Study researchers will
analyze the blood for evidence of microchimerism. Participants with microchimerism will
undergo additional blood collection at Months 12, 18, 24, 30, and 36. Information will be
collected from all participants on health status, injury characteristics, hospital care,
blood transfusion details, and blood donor characteristics.
;
Observational Model: Cohort, Time Perspective: Prospective
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT04554212 -
Blood Flow Restriction Training After Patellar INStability
|
N/A | |
Suspended |
NCT02932176 -
Machine Learning for Handheld Vascular Studies
|
||
Recruiting |
NCT04803253 -
Study of the Social and Professional Reintegration Improvements Using a Set of Solutions for Upper Limb Amputation
|
N/A | |
Completed |
NCT00116337 -
Spinal Cord Stimulation to Restore Cough
|
N/A | |
Completed |
NCT03463720 -
Outcome for Patients With War-Associated Extremity Wound Infection
|
N/A | |
Completed |
NCT03113253 -
TRANexamic Acid to Reduce Bleeding in BURN Surgery
|
Phase 4 | |
Not yet recruiting |
NCT05492903 -
COMmunity of Practice And Safety Support for Navigating Pain (COMPASS-NP)
|
N/A | |
Terminated |
NCT02909231 -
One-year Patient Reported Outcomes Following Hospitalization for Trauma
|
N/A | |
Completed |
NCT02432456 -
Ketamine Infusion Therapy for the Management of Acute Pain in Adult Rib Fracture Patients
|
Phase 4 | |
Completed |
NCT02744144 -
Wound Bacterial Microbiota and Their Antibiotic Resistance
|
N/A | |
Completed |
NCT02266771 -
Impact of V.A.C. Veraflo Therapy in Wounds Requiring Debridement Within an Orthopedic Practice
|
N/A | |
Completed |
NCT02394821 -
Odor Management in Fungating Wounds Comparing Metronidazole and Polihexanide
|
Phase 3 | |
Not yet recruiting |
NCT01665963 -
Efficacy of TopClosure(C)System in Healing Complicated Pacemaker Wounds
|
N/A | |
Completed |
NCT00151112 -
Comparison of Two Different Procedures for Plexus Anesthesia
|
N/A | |
Not yet recruiting |
NCT03872544 -
Short Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds
|
||
Recruiting |
NCT04596124 -
Effectiveness and Tolerability of Fitostimoline Plus Cream and Gauze vs Connettivina Bio Plus Cream and Gauze
|
N/A | |
Recruiting |
NCT05800834 -
Benefits of Morphine Gel for Pain Reduction in Patients With Cancer Wounds
|
Phase 2 | |
Enrolling by invitation |
NCT03880188 -
Long Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds
|
||
Terminated |
NCT04775316 -
Prospective, International, Multicenter, Observational Study to Evaluate the Clinical Performance and Safety of a Silicone-coated Transparent Postoperative Dressing
|
||
Enrolling by invitation |
NCT03312504 -
Implementing a School Prevention Program to Reduce Injuries Through Neuromuscular Training
|
N/A |