Wound Healing Clinical Trial
Official title:
A Phase 1 Randomized, Prospective, Within-Subject, Double-Blind, Vehicle-Controlled, Dose-Escalation Study to Evaluate the Safety, Tolerability and Clinical Effect of Nexagon™ in Full-Thickness Punch Wounds
Verified date | April 2009 |
Source | CoDa Therapeutics Inc. |
Contact | n/a |
Is FDA regulated | No |
Health authority | New Zealand: Medsafe |
Study type | Interventional |
Nexagon™ is a novel compound that promotes wound healing by temporarily disrupting cellular communication at the wound site, thereby promoting accelerated healing, reducing inflammation and pain. This randomized double-blind study will assess the safety, tolerability and clinical effect of Nexagon™ when applied to skin wounds created by punch biopsy in healthy volunteers. 43 healthy, fair-skinned males and females between ages 18-40 will be enrolled. Subjects will be reviewed again at 3 months and 9 months for follow-up safety assessments and wound appearance evaluation.
Status | Completed |
Enrollment | 43 |
Est. completion date | April 2009 |
Est. primary completion date | January 2009 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years to 40 Years |
Eligibility |
Inclusion Criteria: 1. Healthy male or female subjects. 2. Fair skinned (Fitzpatrick Classification Level I - III). 3. Aged between 18 and 40 years inclusive. 4. Subjects who are able to comply with all study procedures, including follow-up assessment visits. 5. Subjects who are willing and able to give written informed consent to take part in the study. Exclusion Criteria: 1. Subjects who have pigmented skin due to an increased susceptibility to hypertrophic and keloid scarring (Fitzpatrick Classification Level IV - VI). 2. Subjects who are known hypertrophic or keloid scar formers. 3. Subjects who smoke. 4. Subjects with a body mass index of greater than 30 kg/m2. 5. Subjects with bleeding disorders or taking anti-coagulants. 6. Subjects with any other skin lesion sites or a chronic or currently active skin disorder, which would adversely affect the healing of the acute wounds or which involve the areas to be examined in this study. 7. Subjects taking or who have taken prescribed drugs in the 30 days prior to Day 0, in particular, topical or systemic steroids, anti-inflammatories, anti-coagulants, anti-proliferative drugs, or antibiotics. 8. Subjects who regularly take aspirin, ginseng, gilboa, Alka Seltzer or any other over-the-counter medicine or complimentary health product that can affect the blood clotting process. 9. Subjects with a history of clinically relevant allergies. 10. Subjects with tattoos, scars or abrasions at the site to be studied. 11. Subjects with any clinically significant abnormality following review of pre-study laboratory data and physical examination. 12. Subjects showing evidence of drug abuse. 13. Subjects with any clinically significant mental illness in the opinion of the Investigator. 14. Females who are currently pregnant or breast-feeding. Females of child-bearing potential must commit to consistent and correct use of an acceptable method of birth control, as defined the protocol. 15. Subjects who have a past or present disease, which as judged by the Investigator may affect the safety of the subject or the outcome of the study. 16. Subjects who have participated in a clinical study within the 30 days prior to Day 0. |
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
New Zealand | Auckland Clinical Studies | Auckland |
Lead Sponsor | Collaborator |
---|---|
CoDa Therapeutics Inc. |
New Zealand,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Assessed by the incidence of adverse events from the time of application of the investigational product | Until the end of the study. | Yes | |
Secondary | Time to complete closure of the wounds | 35 days post-application | No | |
Secondary | Rate of healing | 35 days post application | No | |
Secondary | Clinical assessment by rating scales | 35 days post application | No | |
Secondary | Pain | 35 days post application | No |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT05045183 -
A Study to Assess Wound Healing Efficacies of Different Clean, Treat, and Protect Wound Care Regimens Compared to Standard of Care and Untreated
|
N/A | |
Enrolling by invitation |
NCT04613336 -
Efficacy of Topical Heparin Spray on Donor Site Wound Healing Time Compared to Conventional Dressing Among Patients Undergoing Split Thickness Skin Grafting
|
||
Recruiting |
NCT02241811 -
Wound Treatment With 3% Sodium Pentaborate Pentahydrate
|
Phase 1 | |
Completed |
NCT02797899 -
Effect of PRF Palatal Bandage on Pain Scores and Wound Healing After Free Gingival Graft
|
N/A | |
Completed |
NCT01227759 -
Tyrosur® Gel-Investigation on Wound Healing Efficacy
|
Phase 2 | |
Completed |
NCT01061502 -
Efficacy Study of a Bioelectric Dressing to Treat Skin Graft Donor Site Wounds
|
Phase 1/Phase 2 | |
Completed |
NCT00977951 -
Genomic Changes Associated With the Use of Intradermal Avotermin (Juvista) in Small Wounds in Healthy Male Subjects
|
Phase 1/Phase 2 | |
Not yet recruiting |
NCT03872544 -
Short Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds
|
||
Enrolling by invitation |
NCT03880188 -
Long Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds
|
||
Recruiting |
NCT05191082 -
Manufacturing, Characterization and Evaluation of the Effect of Silk Fibroin Membranes, Loaded or Not With Neurotensins on Open Wounds in the Palate
|
N/A | |
Enrolling by invitation |
NCT05942235 -
The Use of Microlearning in Nursing Education
|
||
Completed |
NCT03433820 -
Wound Healing in Healthy Volunteers
|
N/A | |
Withdrawn |
NCT02383992 -
Postoperative Care of Sutured Wounds
|
N/A | |
Recruiting |
NCT02034539 -
VADOplex Critical Limb Ischemia Study
|
Phase 2/Phase 3 | |
Recruiting |
NCT01680042 -
Clinical Effect of Phenytoin Mucoadhesive Paste on Wound Healing After Oral Biopsy
|
Phase 1 | |
Completed |
NCT01734317 -
An Open Single-centre Investigation Evaluating Efficacy in Second Degree Partial Thickness Burns Using a Silicone Contact Layer Containing Silver.
|
N/A | |
Completed |
NCT01115218 -
The Influence of Anterior Chamber Fluid Mediators on the Success Rate of Trabeculectomy
|
||
Withdrawn |
NCT01008111 -
Wound Healing of Incisional Wounds for Bilateral Hernia Repair
|
Phase 1 | |
Completed |
NCT00984503 -
Investigation of the Accelerated Healing and Anti-scarring Potential of Avotermin (Juvista) in Split Skin Graft Donor Sites
|
Phase 2 | |
Terminated |
NCT00177060 -
Topical Hydromorphone for Wound Healing
|
Phase 1/Phase 2 |