Topical Hydromorphone for Wound Healing

Status Terminated

Clinical Trial Summary

The hypothesis is that topical opioids will hasten wound healing in humans.

Clinical Trial Description

This is based on our published data that morphine is a powerful stimulant of angiogenesis and our preclinical study of wounds in rats which demonstrate that topical opioids (morphine, hydromorphone and fentanyl) hasten healing of punch biopsy wounds. This study will focus on hydromorphone which was more powerful than morphine as a wound-healer in the rat study. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind, Primary Purpose: Treatment

Related Conditions & MeSH terms

Wound Healing

Clinical Trial Details

NCT number	NCT00177060
Study type	Interventional
Source	University of Minnesota - Clinical and Translational Science Institute
Contact
Status	Terminated
Phase	Phase 1/Phase 2
Start date	October 2003
Completion date	May 2007

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05045183` - A Study to Assess Wound Healing Efficacies of Different Clean, Treat, and Protect Wound Care Regimens Compared to Standard of Care and Untreated	N/A
Enrolling by invitation	`NCT04613336` - Efficacy of Topical Heparin Spray on Donor Site Wound Healing Time Compared to Conventional Dressing Among Patients Undergoing Split Thickness Skin Grafting
Recruiting	`NCT02241811` - Wound Treatment With 3% Sodium Pentaborate Pentahydrate	Phase 1
Completed	`NCT02797899` - Effect of PRF Palatal Bandage on Pain Scores and Wound Healing After Free Gingival Graft	N/A
Completed	`NCT01227759` - Tyrosur® Gel-Investigation on Wound Healing Efficacy	Phase 2
Completed	`NCT01061502` - Efficacy Study of a Bioelectric Dressing to Treat Skin Graft Donor Site Wounds	Phase 1/Phase 2
Completed	`NCT00736593` - A Study Evaluating Nexagon™ in the Treatment of Skin Wounds.	Phase 1
Completed	`NCT00977951` - Genomic Changes Associated With the Use of Intradermal Avotermin (Juvista) in Small Wounds in Healthy Male Subjects	Phase 1/Phase 2
Not yet recruiting	`NCT03872544` - Short Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds
Enrolling by invitation	`NCT03880188` - Long Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds
Recruiting	`NCT05191082` - Manufacturing, Characterization and Evaluation of the Effect of Silk Fibroin Membranes, Loaded or Not With Neurotensins on Open Wounds in the Palate	N/A
Enrolling by invitation	`NCT05942235` - The Use of Microlearning in Nursing Education
Completed	`NCT03433820` - Wound Healing in Healthy Volunteers	N/A
Withdrawn	`NCT02383992` - Postoperative Care of Sutured Wounds	N/A
Recruiting	`NCT02034539` - VADOplex Critical Limb Ischemia Study	Phase 2/Phase 3
Recruiting	`NCT01680042` - Clinical Effect of Phenytoin Mucoadhesive Paste on Wound Healing After Oral Biopsy	Phase 1
Completed	`NCT01734317` - An Open Single-centre Investigation Evaluating Efficacy in Second Degree Partial Thickness Burns Using a Silicone Contact Layer Containing Silver.	N/A
Completed	`NCT01115218` - The Influence of Anterior Chamber Fluid Mediators on the Success Rate of Trabeculectomy
Withdrawn	`NCT01008111` - Wound Healing of Incisional Wounds for Bilateral Hernia Repair	Phase 1
Completed	`NCT00984503` - Investigation of the Accelerated Healing and Anti-scarring Potential of Avotermin (Juvista) in Split Skin Graft Donor Sites	Phase 2