Wound Heal Clinical Trial
Official title:
Effect of Topically Applied Melatonin (N-ACETYL-5-METHOXY TRYPTAMINE) Loaded Gelatin Sponge on Palatal Wound Healing (Randomized Controlled Clinical Trial)
The aim of the study is to assess the effect of topical melatonin loaded gelatin sponge on donor palatal site healing, after palatal graft harvesting.
Status | Recruiting |
Enrollment | 26 |
Est. completion date | December 20, 2022 |
Est. primary completion date | September 20, 2022 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 20 Years to 50 Years |
Eligibility | Inclusion Criteria 1. Patients who have at least one site of natural dentition or dental implants that need to be treated by free palatal graft surgery for indications including progressive recession, planned prosthodontics, presence of a mucogingival deformity, or a lack of keratinized gingiva. 2. Patients who have at least 4 mm thickness of palatal mucosa (at donor site) Exclusion Criteria: 1. History of smoking. 2. Patients who have any known disease that interfere with periodontal surgery. 3. Patients who have any dermal or autoimmune diseases. 4. Patients who have any previous adverse reactions to the products (or similar products) used in this study. 5. Pregnant and lactating women. 6. Patients who have a palatal infection. |
Country | Name | City | State |
---|---|---|---|
Egypt | Alexandria University | Alexandria |
Lead Sponsor | Collaborator |
---|---|
Salma Nabil |
Egypt,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | palatal wound healing | Standardized clinical photographs of the palatal surgical sites will be taken and will be imported into a software program (ImageJ 1.49v) and wound areas will be calculated by computerized planimetry (Difference in remaining wound area [mm2]) | Up to 2 weeks | |
Secondary | Intensity of pain | by visual analogue scale Patients will be asked to grade the severity of their symptoms on VAS that ranges from (0-100 mm) | Up 2 weeks |
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