Non-Invasive Brain Stimulation to Control Large-Scale Brain Networks

Working Memory Clinical Trial

Official title:

Traveling Wave Transcranial Alternating Current Stimulation for the Control of Large-Scale Brain Networks

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04680481
• Other study ID #: STUDY00004009
• Secondary ID: RF1MH124909
• Status: Recruiting
• Phase: N/A
• Start date: November 1, 2020
• Est. completion date: November 1, 2024

Study information

• Verified date: February 2024
• Source: University of Minnesota
• Contact: Alexander Opitz, PhD
• Phone: 612-624-1094
• Email: aopitz[@]umn.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This project will assess the feasibility of traveling wave transcranial alternating current stimulation (tACS) to modify working memory performance and large-scale brain connectivity in surgical epilepsy patients.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 16
• Est. completion date: November 1, 2024
• Est. primary completion date: November 1, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

1. the patient can consent for themselves;

2. the patient has or is scheduled for surgically implanted electrodes for the purposes of phase II epilepsy surgical evaluation;

3. age 18+ years old;

Exclusion Criteria:

1. diminished capacity to consent;

Related Conditions & MeSH terms

• Working Memory

Intervention

Device:
• Transcranial alternating current stimulation
Traveling wave transcranial alternating current stimulation will be applied at 4 Hz and 23 Hz over frontal and parietal brain areas in a randomized counterbalanced order.

Locations

Country	Name	City	State
United States	University of Minnesota	Minneapolis	Minnesota

Sponsors (2)

Lead Sponsor	Collaborator
University of Minnesota	National Institute of Mental Health (NIMH)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Electrophysiological outcomes	Changes in spectral power and coherence of the local field potentials during transcranial electric stimulation relative to no stimulation periods.	Immediate effect during stimulation
Primary	Working memory outcomes	Changes in working memory performance as measured with the N-back task (quantified with d-prime) during stimulation.	Immediate effect during stimulation